Candan Ozlem, Fırat Sevde Nur
Department of Ophthalmology, University of Health Sciences Ankara Training and Research Hospital, Ankara 06320, Türkiye.
Department of Endocrinology and Metabolism, University of Health Sciences Ankara Training and Research Hospital, Ankara 06320, Türkiye.
Int J Ophthalmol. 2025 Oct 18;18(10):1949-1957. doi: 10.18240/ijo.2025.10.19. eCollection 2025.
To analyze the ocular findings of patients who received lifelong leptin therapy due to congenital leptin deficiency (CLD), an extremely rare condition.
A prospective, cross-sectional comparative study was performed on six patients with CLD and 13 healthy age- and sex-matched controls. The central corneal thickness (CCT), anterior chamber depth (ACD), axial length (AL), keratometry (K1, K2), optical coherence tomography (OCT), and OCT angiography parameters were compared between the leptin and control groups at the baseline visit. The change in these measurements in leptin patients over a two-year period was analyzed.
CLD patients had lower mean AL, ACD, and CCT (≤0.012 for all). Mean K1, K2 (≤0.047 for both), choroidal thickness (≤0.001), and central ganglion cell layer (GCL) thickness (=0.029) were higher in the leptin group. Perifoveal superficial capillary plexus (SCP) density was decreased in all quadrants except the temporal region (<0.05), and parafoveal deep capillary plexus (DCP) density was decreased in the superior hemisphere, temporal quadrant (≤0.036 for both) and nasal quadrant (=0.048) in the leptin group. During the two-year follow-up, no changes in anterior and posterior segment measurements were observed in the leptin patients, except for subfoveal choroidal thickness (<0.001).
CLD patients exhibit structural alterations in both the anterior and posterior segments of the eye, including notable changes in retinal and choroidal vasculature. However, there is limited evidence concerning the influence of leptin therapy on the eye.
分析因先天性瘦素缺乏症（CLD，一种极为罕见的病症）而接受终身瘦素治疗的患者的眼部检查结果。
对6例CLD患者和13例年龄及性别匹配的健康对照者进行了一项前瞻性横断面比较研究。在基线访视时，比较了瘦素组和对照组之间的中央角膜厚度（CCT）、前房深度（ACD）、眼轴长度（AL）、角膜曲率（K1、K2）、光学相干断层扫描（OCT）和OCT血管造影参数。分析了瘦素治疗患者在两年期间这些测量值的变化。
CLD患者的平均AL、ACD和CCT较低（均≤0.012）。瘦素组的平均K1、K2（均≤0.047）、脉络膜厚度（≤0.001）和中央神经节细胞层（GCL）厚度（=0.029）较高。除颞侧区域外，所有象限的黄斑周围浅表毛细血管丛（SCP）密度均降低（<0.05），瘦素组上半球、颞侧象限（均≤0.036）和鼻侧象限（=0.048）的黄斑旁深部毛细血管丛（DCP）密度降低。在两年的随访期间，除黄斑下脉络膜厚度外（<0.001），瘦素治疗患者的眼前段和眼后段测量值均未观察到变化。
CLD患者的眼部前段和后段均表现出结构改变，包括视网膜和脉络膜血管系统的显著变化。然而，关于瘦素治疗对眼睛影响的证据有限。
