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成熟前牙开放根尖与慢性根尖脓肿的牙髓再生治疗:一例4年随访病例报告

Regenerative Endodontic Procedure of a Mature Anterior Tooth With Open Apex and Chronic Apical Abscess: A Case Report With 4-Years Follow-Up.

作者信息

Alcalde Murilo Priori, de Oliveira Neto Raimundo Sales, de Almeida Estela Franzolin Pires, Furlan Renan Diego, de Souza Paulo Roberto Jara, Vivan Rodrigo Ricci, Amoroso-Silva Pablo Andres, Duarte Marco Antônio Húngaro, da Silva Guilherme Ferreira

机构信息

Department of Dentistry, Endodontics and Dental Materials, Bauru Dental School University of São Paulo Bauru Brazil.

Department of Dentistry Unisagrado Bauru Brazil.

出版信息

Clin Case Rep. 2025 Sep 22;13(9):e70911. doi: 10.1002/ccr3.70911. eCollection 2025 Sep.

DOI:10.1002/ccr3.70911
PMID:40995393
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12453967/
Abstract

This case report describes the successful treatment of a mature anterior tooth with an open apex and chronic apical abscess using a regenerative endodontic procedure. A 36-year-old man with a history of trauma to tooth 11 at age 10 presented with incomplete root development and an asymptomatic chronic apical abscess. Cone beam tomography revealed a periradicular lesion with buccal bone plate loss. After biomechanical preparation using K-type files and irrigation with 1% sodium hypochlorite, calcium hydroxide was placed as intracanal medication for 14 days. Bleeding was induced by overinstrumenting the periapical tissues with a #25 K-file, and a bioceramic material was placed over the blood clot, followed by a composite resin coronal seal. At the 4-year follow-up, the patient was asymptomatic, with complete bone plate formation and no periradicular lesion or root resorption, although no hard tissue formation or changes in root canal morphology were observed.

摘要

本病例报告描述了使用再生性牙髓治疗方法成功治疗一颗根尖开放且患有慢性根尖脓肿的成熟前牙。一名36岁男性,10岁时曾有11号牙外伤史,现表现为牙根发育不全及无症状性慢性根尖脓肿。锥形束断层扫描显示根尖周病变伴有颊侧骨板缺失。使用K型锉进行生物力学预备并用1%次氯酸钠冲洗后,放置氢氧化钙作为根管内药物14天。用#25 K锉过度预备根尖周组织诱导出血,在血凝块上放置生物陶瓷材料,随后进行复合树脂冠部封闭。在4年随访时,患者无症状,骨板完全形成,无根尖周病变或牙根吸收,尽管未观察到硬组织形成或根管形态改变。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d65/12453967/99ac24088a78/CCR3-13-e70911-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d65/12453967/cec4e3f25962/CCR3-13-e70911-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d65/12453967/262d7e2fc6e8/CCR3-13-e70911-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d65/12453967/33c3374fc6d3/CCR3-13-e70911-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d65/12453967/02eddc19edc2/CCR3-13-e70911-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d65/12453967/99ac24088a78/CCR3-13-e70911-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d65/12453967/cec4e3f25962/CCR3-13-e70911-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d65/12453967/262d7e2fc6e8/CCR3-13-e70911-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d65/12453967/33c3374fc6d3/CCR3-13-e70911-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d65/12453967/02eddc19edc2/CCR3-13-e70911-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d65/12453967/99ac24088a78/CCR3-13-e70911-g001.jpg

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本文引用的文献

1
Tooth vitality and periapical healing: is Biodentine at par with MTA in regenerative endodontics?牙齿活力与根尖周愈合:在再生性牙髓治疗中,BioRoot RCS生物活性玻璃陶瓷与矿物三氧化物凝聚体相当吗?
Evid Based Dent. 2025 Mar;26(1):6-7. doi: 10.1038/s41432-025-01109-8. Epub 2025 Jan 31.
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What is the impact of Endodontic Irrigant Solutions on the Viability of Stem Cells from Apical Papilla in an in-vitro setting: A Systematic Review.根管冲洗液在体外环境中对根尖乳头干细胞活力的影响:一项系统评价
Saudi Dent J. 2024 Sep;36(9):1170-1178. doi: 10.1016/j.sdentj.2024.07.006. Epub 2024 Jul 14.
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Regenerative endodontic treatment and traumatic dental injuries.
再生性牙内治疗和外伤性牙损伤。
Dent Traumatol. 2024 Dec;40(6):618-635. doi: 10.1111/edt.12979. Epub 2024 Jul 11.
4
Revolutionizing Endodontics: Innovative Approaches for Treating Mature Teeth With Closed Apices and Apical Lesions: A Report of Two Cases.牙髓病学的革命:治疗闭合根尖和根尖病变成熟恒牙的创新方法:两例报告。
J Endod. 2024 May;50(5):596-601. doi: 10.1016/j.joen.2024.02.012. Epub 2024 Feb 20.
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Success and Complication Rates of Revascularization Procedures for Immature Necrotic Teeth: A Systematic Review.未成熟坏死牙血运重建术的成功率和并发症发生率:一项系统评价
Cureus. 2023 Dec 30;15(12):e51364. doi: 10.7759/cureus.51364. eCollection 2023 Dec.
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Advances in scaffolds used for pulp-dentine complex tissue engineering: A narrative review.用于牙髓-牙本质复合体组织工程的支架研究进展:一项叙述性综述。
Int Endod J. 2022 Dec;55(12):1277-1316. doi: 10.1111/iej.13826. Epub 2022 Sep 16.
7
Microbiome Changes during Regenerative Endodontic Treatment Using Different Methods of Disinfection.使用不同消毒方法的牙髓再生治疗过程中的微生物组变化。
J Endod. 2022 Oct;48(10):1273-1284. doi: 10.1016/j.joen.2022.07.004. Epub 2022 Aug 27.
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"Meta-analysis of regenerative endodontics outcomes with antibiotics pastes and calcium hydroxide. The apex of the iceberg".抗生素糊剂与氢氧化钙用于再生牙髓治疗效果的Meta分析:冰山一角
J Oral Biol Craniofac Res. 2022 Jan-Feb;12(1):90-98. doi: 10.1016/j.jobcr.2021.11.005. Epub 2021 Nov 10.
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Regenerative Endodontic Procedures for the Treatment of Necrotic Mature Teeth with Apical Periodontitis: A Systematic Review and Meta-analysis of Randomized Controlled Trials.再生性牙髓治疗术治疗伴有根尖周炎的坏死成熟恒牙的系统评价和 Meta 分析:随机对照试验。
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PRICE 2020 guidelines for reporting case reports in Endodontics: explanation and elaboration.PRICE 2020 牙髓病学病例报告报告指南:说明与详述。
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