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对一颗牙髓坏死且伴有根尖周病变的未成熟恒牙进行的再生性牙髓治疗。

Regenerative Endodontic Treatment in an Immature Permanent Tooth With Necrotic Pulp and Periradicular Lesion.

作者信息

Adel Mamak, Asgari Zohreh

机构信息

Department of Endodontics, Dental Caries Prevention Research Center Qazvin University of Medical Sciences Qazvin Iran.

Department of Endodontics, School of Dentistry Qazvin University of Medical Sciences Qazvin Iran.

出版信息

Clin Case Rep. 2025 Sep 24;13(10):e70941. doi: 10.1002/ccr3.70941. eCollection 2025 Oct.

DOI:10.1002/ccr3.70941
PMID:41001164
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12459079/
Abstract

Managing necrotic immature permanent teeth with an open apex presents a treatment challenge. Regenerative endodontic procedures have emerged as biologically based approaches for these cases, suggesting an alternative to conventional apexification. This report describes successful revascularization of an immature mandibular second premolar with a chronic apical abscess. Following canal disinfection with NaOCl irrigation and applying a calcium hydroxide as an intracanal medicament, a scaffold was created by inducing a blood clot within the canal. During follow-up sessions, the tooth remained asymptomatic and clinically functional. Radiographic evidence demonstrated ongoing apical root development with increases in both root length and dentinal-wall thickness, along with signs of apical closure. The treatment outcome supports the premise that conservative pulp revascularization can promote complete root maturation by preserving the vitality of dental pulp stem cells and providing a conducive environment for pulp regeneration.

摘要

处理根尖开放的坏死未成熟恒牙是一项治疗挑战。再生性牙髓治疗程序已成为针对这些病例的基于生物学的方法,为传统根尖诱导成形术提供了一种替代方案。本报告描述了一例患有慢性根尖脓肿的未成熟下颌第二前磨牙成功实现血管再生的病例。在用次氯酸钠冲洗进行根管消毒并将氢氧化钙作为根管内药物应用后,通过在根管内诱导形成血凝块创建了一个支架。在随访期间,该牙齿无症状且具有临床功能。影像学证据显示根尖牙根持续发育,牙根长度和牙本质壁厚度均增加,同时伴有根尖闭合的迹象。治疗结果支持这样一个前提,即保守性牙髓血管再生可通过保留牙髓干细胞的活力并为牙髓再生提供有利环境来促进牙根完全成熟。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec62/12459079/d52d39e66b69/CCR3-13-e70941-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec62/12459079/f346bc8f50db/CCR3-13-e70941-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec62/12459079/690e935bdb0f/CCR3-13-e70941-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec62/12459079/d52d39e66b69/CCR3-13-e70941-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec62/12459079/f346bc8f50db/CCR3-13-e70941-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec62/12459079/690e935bdb0f/CCR3-13-e70941-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec62/12459079/d52d39e66b69/CCR3-13-e70941-g001.jpg

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本文引用的文献

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Nonsurgical Management of Perforating Internal Root Resorption in Maxillary Invaginated Lateral Incisor Using Cold Ceramic.使用冷陶瓷对上颌埋伏侧切牙穿孔性内吸收进行非手术治疗
Clin Case Rep. 2025 May 20;13(5):e70526. doi: 10.1002/ccr3.70526. eCollection 2025 May.
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Expert consensus on regenerative endodontic procedures.再生性牙髓治疗程序的专家共识。
Int J Oral Sci. 2022 Dec 1;14(1):55. doi: 10.1038/s41368-022-00206-z.
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Resistance to fracture of simulated external cervical resorption cavities repaired with different materials.用不同材料修复的模拟外源性颈椎吸收腔的抗骨折性能。
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Tooth resorption-Part 2: A clinical classification.牙吸收-第 2 部分:临床分类。
Dent Traumatol. 2022 Aug;38(4):267-285. doi: 10.1111/edt.12762. Epub 2022 May 23.
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Comparative evaluation of the effect of cold ceramic and MTA-Angelus on cell viability, attachment and differentiation of dental pulp stem cells and periodontal ligament fibroblasts: an in vitro study.冷瓷和 MTA-Angelus 对牙髓干细胞和牙周膜成纤维细胞活力、黏附及分化影响的比较评价:一项体外研究。
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J Oral Biol Craniofac Res. 2022 Jan-Feb;12(1):90-98. doi: 10.1016/j.jobcr.2021.11.005. Epub 2021 Nov 10.
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Regenerative Endodontic Procedures for the Treatment of Necrotic Mature Teeth with Apical Periodontitis: A Systematic Review and Meta-analysis of Randomized Controlled Trials.再生性牙髓治疗术治疗伴有根尖周炎的坏死成熟恒牙的系统评价和 Meta 分析:随机对照试验。
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