人胎盘的免疫组织学和洗脱研究。
Immunohistological and elution studies of the human placenta.
作者信息
McCormick J N, Faulk W P, Fox H, Fudenberg H H
出版信息
J Exp Med. 1971 Jan 1;133(1):1-18. doi: 10.1084/jem.133.1.1.
An immunohistological survey of 28 full-term human placentas has demonstrated deposits of IgG, beta1C, beta1E, and fibrinogen/fibrin in areas of fibrinoid necrosis and on the trophoblast basement membrane in approximately 35% of placental villi. Traces of IgM were detected at similar sites in 18 of 28 full-term placentas. In 11 specimens of immature placentas (10-18 wk gestation) traces of IgG and beta1C and deposits of fibrinogen/fibrin were also present, but IgM was not detected in this material. IgG was recovered in acidic eluates from an homogenized placenta which behaved as an antibody reactive with unidentified material present in fibrinoid deposits and on the thickened trophoblast basement membrane of some villi. It could not be determined whether this IgG was derived from the maternal or fetal circulation.
对28份足月人类胎盘进行的免疫组织学调查显示，在约35%的胎盘绒毛中，类纤维蛋白坏死区域以及滋养层基底膜上存在IgG、β1C、β1E和纤维蛋白原/纤维蛋白沉积物。在28份足月胎盘中的18份中，在类似部位检测到微量IgM。在11份未成熟胎盘标本（妊娠10 - 18周）中，也存在微量IgG和β1C以及纤维蛋白原/纤维蛋白沉积物，但在该材料中未检测到IgM。从匀浆胎盘中的酸性洗脱液中回收了IgG，其表现为与类纤维蛋白沉积物以及某些绒毛增厚的滋养层基底膜中存在的未知物质发生反应的抗体。无法确定这种IgG是来自母体循环还是胎儿循环。
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