Faulk W P, Jarret R, Keane M, Johnson P M, Boackle R J
Clin Exp Immunol. 1980 May;40(2):299-305.
The localization and distribution of complement components in term and pre-term normal human placentae have been studied by using haemadsorption and immunofluorescence experiments. The components Clq, C4, C5, C6 and C9 were identified in characteristic locations. Receptors for C3 and C4 were not found. Complement was associated with certain stromal cells, areas of fibrinoid necrosis within the trophoblastic mantle, and in the walls and endothelia of foetal stem vessels. Activation of the complement system on trophoblastic basement membranes (TBM) did not appear to involve the early reacting components of the classical pathway of complement activation, because C1q, C4 and C2 could not be identified on TBM. The C6 component was identified within cytoplasmic granules of foetal stem vessel endothelia, suggesting that it may be synthesized by these cells. These findings put forward the possibility that complement may play an immunobiological role in the materno-foetal relationship during normal human pregnancy.
通过血细胞吸附和免疫荧光实验，对足月和早产的正常人类胎盘补体成分的定位和分布进行了研究。已在特征性位置鉴定出补体成分C1q、C4、C5、C6和C9。未发现C3和C4的受体。补体与某些基质细胞、滋养层内的类纤维蛋白坏死区域以及胎儿主干血管的壁和内皮有关。滋养层基底膜（TBM）上补体系统的激活似乎不涉及补体激活经典途径的早期反应成分，因为在TBM上未鉴定出C1q、C4和C2。在胎儿主干血管内皮的细胞质颗粒内鉴定出C6成分，表明它可能由这些细胞合成。这些发现提出了补体可能在正常人类妊娠期间母胎关系中发挥免疫生物学作用的可能性。
