人类母体细胞对胎盘抗原的介导免疫反应。
Human maternal cell mediated immune reaction to placental antigens.
作者信息
Youtananukorn V, Matangkasombut P
出版信息
Clin Exp Immunol. 1972 Aug;11(4):549-56.
Abstract
The macrophage migration inhibition test was employed to show reactivity of maternal peripheral blood leucocytes to placental antigens. Four to 5 days after delivery, all of forty-one postpartum women tested had leucocytes in their blood that reacted with pooled antigens from five placentas. When antigens from a single placenta were used leucocytes from only the woman who donated that placenta and one of nine unrelated postpartum women were reactive. Leucocytes from seventeen-control subjects, including nulligravidous women, were non-reactive with either the single or the pooled placental antigens. The results indicated that the mothers may be specifically sensitized, as far as the cell mediated immune response is concerned, by the placenta during pregnancy.
摘要
采用巨噬细胞移动抑制试验来显示母体外周血白细胞对胎盘抗原的反应性。分娩后4至5天，接受检测的41名产后妇女的血液中的白细胞均与来自5个胎盘的混合抗原发生反应。当使用单个胎盘的抗原时，只有捐赠该胎盘的妇女以及9名无亲缘关系的产后妇女中的1人的白细胞有反应。包括未孕妇女在内的17名对照受试者的白细胞对单个或混合胎盘抗原均无反应。结果表明，就细胞介导的免疫反应而言，母亲在怀孕期间可能会被胎盘特异性致敏。
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