Saad Muhammad, Ali Dua, Khan Taimor Mohammed, Batool Ruqiat Masooma, Arshad Muhammad Sameer, Collins Peter, Ahmed Raheel
Department of Medicine, Dow University of Health Sciences, Karachi, Pakistan.
Baylor Scott and White Research Institute, Dallas, Texas, USA.
Endocrinol Diabetes Metab. 2025 Sep;8(5):e70092. doi: 10.1002/edm2.70092.
Cancer and diabetes are major public health concerns, with diabetes linked to increased cancer-related mortality. However, national trends and disparities remain underexplored.
Using CDC WONDER data, we analysed deaths where both diabetes and cancer were listed as causes. Age-adjusted mortality rates (AAMRs) were calculated for diabetic cancer patients aged ≥ 25 years and stratified by demographics and geography. Joinpoint regression estimated annual percent changes (APCs) and average annual percent changes (AAPCs).
From 1999 to 2019, 699,007 cancer-related deaths occurred among individuals with diabetes. The overall AAMR increased from 15.06 to 15.23 per 100,000 (AAPC: +0.07%; p = 0.20), with a rise from 1999 to 2003, a decline from 2003 to 2015, and a resurgence from 2015 to 2019. Men (AAMR: 20.83) had higher mortality than women (AAMR: 11.80). Non-Hispanic Black individuals had the highest AAMRs (23.72), but NH American Indian/Alaska Natives had the largest increase (AAPC: 0.60). The Midwest (AAMR: 17.03) and rural areas (AAMR: 18.70) had the highest mortality, with rural rates rising significantly (AAPC: 0.92). Gastrointestinal cancers were the leading cause (AAMR: 4.31), followed by haematological (AAMR: 1.80), prostate (AAMR: 1.59), and breast cancer (AAMR: 1.38).
Cancer-related mortality in individuals with diabetes has increased, with notable disparities. Targeted interventions, screening, and better diabetes management are essential to reducing risks in high-risk populations.
癌症和糖尿病是主要的公共卫生问题，糖尿病与癌症相关死亡率增加有关。然而，全国趋势和差异仍未得到充分研究。
利用美国疾病控制与预防中心（CDC）的WONDER数据，我们分析了将糖尿病和癌症均列为死因的死亡情况。计算了年龄≥25岁的糖尿病癌症患者的年龄调整死亡率（AAMRs），并按人口统计学和地理区域进行分层。连接点回归估计了年度百分比变化（APCs）和平均年度百分比变化（AAPCs）。
1999年至2019年，糖尿病患者中发生了699,007例癌症相关死亡。总体AAMR从每10万人15.06例增至15.23例（AAPC：+0.07%；p = 0.20），1999年至2003年上升，2003年至2015年下降，2015年至2019年再次上升。男性（AAMR：20.83）的死亡率高于女性（AAMR：11.80）。非西班牙裔黑人的AAMRs最高（23.72），但美国印第安人/阿拉斯加原住民的增幅最大（AAPC：0.60）。中西部地区（AAMR：17.03）和农村地区（AAMR：18.70）的死亡率最高，农村地区的死亡率显著上升（AAPC：0.92）。胃肠道癌症是主要死因（AAMR：4.31），其次是血液系统癌症（AAMR：1.80）、前列腺癌（AAMR：1.59）和乳腺癌（AAMR：1.38）。
糖尿病患者的癌症相关死亡率有所上升，存在显著差异。有针对性的干预、筛查和更好的糖尿病管理对于降低高危人群的风险至关重要。
