Kim Keon, Je Chang-Yun, Seo In Su, Do Yoon Jung, Ro Woong-Bin, Lee Chang-Min
Department of Veterinary Internal Medicine, College of Veterinary Medicine and BK 21 FOUR program, Chonnam National University, Gwangju, Republic of Korea.
Laboratory Animal Medicine, College of Veterinary Medicine, Chonnam National University, Gwangju, Republic of Korea.
Vet Q. 2025 Dec;45(1):2564447. doi: 10.1080/01652176.2025.2564447. Epub 2025 Sep 26.
Canine atopic dermatitis (cAD) is a chronic inflammatory skin condition associated with T helper 2 (Th2)-type immune responses, and recent evidence suggests that periostin, an extracellular matrix protein, may play a role in its pathogenesis. To investigate the significance of serum periostin concentrations in dogs with cAD, this study examined their relationship with disease severity and laboratory parameters, including eosinophil counts and Th2 cytokines such as interleukin (IL)-4 and IL-13. A total of 68 dogs diagnosed with cAD and 21 healthy controls were included, with serum periostin, IL-4, and IL-13 levels measured. Disease severity was assessed using the Canine Atopic Dermatitis Extent and Severity Index (CADESI-04) and the Pruritus Visual Analog Scale (PVAS). The results showed that serum periostin concentrations were significantly higher in dogs with cAD compared to healthy controls and exhibited a positive correlation with CADESI-04 scores, reflecting disease severity. Treatment with prednisolone or oclacitinib led to a significant reduction in serum periostin, IL-4, and IL-13 levels, along with a decrease in eosinophil counts. These findings highlight the potential of serum periostin as a valuable biomarker for assessing cAD severity and monitoring treatment response, emphasizing its clinical relevance as an objective measure.
犬特应性皮炎（cAD）是一种与2型辅助性T细胞（Th2）免疫反应相关的慢性炎症性皮肤病，最近的证据表明，细胞外基质蛋白骨膜蛋白可能在其发病机制中起作用。为了研究血清骨膜蛋白浓度在患有cAD的犬中的意义，本研究考察了其与疾病严重程度及实验室参数的关系，包括嗜酸性粒细胞计数和Th2细胞因子，如白细胞介素（IL）-4和IL-13。总共纳入了68只被诊断为cAD的犬和21只健康对照犬，并检测了血清骨膜蛋白、IL-4和IL-13水平。使用犬特应性皮炎范围和严重程度指数（CADESI-04）和瘙痒视觉模拟量表（PVAS）评估疾病严重程度。结果显示，与健康对照犬相比，患有cAD的犬血清骨膜蛋白浓度显著更高，并且与反映疾病严重程度的CADESI-04评分呈正相关。泼尼松龙或奥克拉替尼治疗导致血清骨膜蛋白、IL-4和IL-13水平显著降低，同时嗜酸性粒细胞计数减少。这些发现凸显了血清骨膜蛋白作为评估cAD严重程度和监测治疗反应的有价值生物标志物的潜力，强调了其作为客观指标的临床相关性。
