Pasierbska Ewa, Dębska-Ślizień Alicja, Imko-Walczuk Beata
Dermatology and Venereology Clinic, COPERNICUS, Independent Public Healthcare Centre, Gdansk, Poland.
Dermatology Department, Provincial Hospital, Elblag, Poland.
Postepy Dermatol Alergol. 2025 Jan 29;42(4):329-335. doi: 10.5114/ada.2024.147199. eCollection 2025 Aug.
Kidney transplantation has become the preferred treatment for end-stage renal disease, significantly enhancing quality of life and life expectancy compared to dialysis. However, immunosuppressive therapy post-transplantation causes various side-effects, including skin and hair disorders. While the literature extensively documents cutaneous malignancies post-transplantation, hair disorders remain less explored. This review synthesizes the existing literature on trichological problems in transplant recipients, focusing on the correlation between immunosuppressive medications and hair disorders. A more concise version might be: The review highlights a discrepancy between patient-reported alopecia rates and physician perceptions, suggesting an underestimation of the issue. It underscores the importance of recognizing and managing trichological complications, which can significantly impact patients' quality of life, especially in some groups such as women experiencing alopecia and in teenagers of both sexes. Further research is needed to better understand the prevalence, patterns, and mechanisms of trichological complications post-transplantation as well as to explore potential therapeutic interventions. Future studies on the etiopathogenesis of these complications can improve patient care and management strategies.
肾移植已成为终末期肾病的首选治疗方法，与透析相比，显著提高了生活质量和预期寿命。然而，移植后的免疫抑制治疗会引起各种副作用，包括皮肤和毛发疾病。虽然文献广泛记录了移植后的皮肤恶性肿瘤，但毛发疾病仍较少被研究。这篇综述综合了关于移植受者毛发问题的现有文献，重点关注免疫抑制药物与毛发疾病之间的相关性。一个更简洁的版本可能是：该综述强调了患者报告的脱发率与医生认知之间的差异，表明该问题被低估了。它强调了认识和处理毛发并发症的重要性，这些并发症会显著影响患者的生活质量，尤其是在一些群体中，如患有脱发的女性和青少年。需要进一步研究以更好地了解移植后毛发并发症的患病率、模式和机制，并探索潜在的治疗干预措施。对这些并发症发病机制的未来研究可以改善患者护理和管理策略。
