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源自颌骨空洞的隐匿性炎症会在女性乳腺癌中激活CCL5/CCR5轴吗？骨免疫学相互作用中的诊断与治疗差距。

Could Silent Inflammation Originating in Jawbone Cavitations Play a Role in Activating the CCL5/CCR5 Axis in Female Breast Cancer? A Diagnostic and Therapeutic Gap in Osteoimmunological Interactions.

作者信息

Vasconcelos E Cruz Joana, Perko Sebastjan, Doebis Cornelia, Notter Florian, Schick Fabian, Lechner Johann

机构信息

Dental Materials, Egas Moniz School of Health & Science, Caparica, Portugal.

Dental Materials, Centro de Investigação Interdisciplinar Egas Moniz (CiiEM), Caparica, Portugal.

出版信息

Onco Targets Ther. 2025 Sep 19;18:1053-1068. doi: 10.2147/OTT.S526033. eCollection 2025.

DOI:10.2147/OTT.S526033
PMID:41001272
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12457831/
Abstract

INTRODUCTION

Breast cancer (BC) is one of the leading causes of cancer mortality worldwide. The chemokine CCL5 and its receptor CCR5 have been demonstrated to be associated with tumour progression, immune evasion, and metastasis.

OBJECTIVE

Recent evidence indicates that chronic inflammatory conditions in the jawbone, specifically fatty degenerative osteonecrosis of the jaw (FDOJ), may serve as a continuous source of CCL5 overexpression, potentially influencing BC development.

METHODS

This multicentre study, conducted in Germany, Portugal and Slovenia, investigated the correlation between FDOJ-related CCL5 expression and BC. Patients undergoing surgical removal of FDOJ areas were examined using advanced imaging (trans alveolar ultrasonography) and multiplex cytokine analysis to detect bone marrow defects and measure CCL5 levels.

RESULTS

The results demonstrated a marked increase in CCL5 expression in FDOJ samples in comparison to healthy jawbone tissue.

DISCUSSION

Statistical analysis revealed a strong correlation between FDOJ and elevated CCL5, thereby supporting the hypothesis that jawbone inflammation may activate the CCL5/CCR5 axis in BC patients. This finding suggests that FDOJ may represent an underrecognized inflammatory comorbidity that contributes to BC progression.

CONCLUSION

The study under discussion highlights a hitherto unidentified osteoimmune mechanism that links inflammation of the jawbone to cancer pathways. It also emphasizes the potential benefit of targeted surgical interventions such as "Jawbone Detox" in reducing chronic CCL5 levels. Such approaches have the potential to offer novel preventive and therapeutic options for patients diagnosed with BC. Further clinical studies are required to confirm the effects of FDOJ treatment on immune function and BC outcomes.

摘要

引言

乳腺癌（BC）是全球癌症死亡的主要原因之一。趋化因子CCL5及其受体CCR5已被证明与肿瘤进展、免疫逃逸和转移有关。

目的

最近的证据表明，颌骨的慢性炎症状态，特别是颌骨脂肪变性性骨坏死（FDOJ），可能是CCL5过表达的持续来源，潜在影响乳腺癌的发展。

方法

这项在德国、葡萄牙和斯洛文尼亚进行的多中心研究，调查了FDOJ相关的CCL5表达与乳腺癌之间的相关性。对接受FDOJ区域手术切除的患者，使用先进成像技术（经牙槽超声检查）和多重细胞因子分析来检测骨髓缺陷并测量CCL5水平。

结果

结果表明，与健康颌骨组织相比，FDOJ样本中CCL5表达显著增加。

讨论

统计分析显示FDOJ与CCL5升高之间存在强相关性，从而支持颌骨炎症可能激活乳腺癌患者CCL5/CCR5轴的假设。这一发现表明，FDOJ可能是一种未被充分认识的炎症合并症，有助于乳腺癌进展。

结论

所讨论的研究突出了一种迄今未被发现的骨免疫机制，该机制将颌骨炎症与癌症途径联系起来。它还强调了“颌骨排毒”等靶向手术干预在降低慢性CCL5水平方面的潜在益处。这些方法有可能为被诊断为乳腺癌的患者提供新的预防和治疗选择。需要进一步的临床研究来证实FDOJ治疗对免疫功能和乳腺癌结局的影响。

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