Bilyalova Alina, Bilyalov Airat, Kozlova Olga, Filatov Nikita, Filimoshina Daria, Gazizova Guzel, Deviatiiarov Ruslan, Titova Angelina, Bydanov Andrey, Mukhamedshina Yana, Shagimardanova Elena, Kiyasov Andrey, Tychinin Dmitry, Woroncow Mary, Gusev Oleg
Institute of Fundamental Medicine and Biology, Kazan Federal University, 420008 Kazan, Russia.
National Medical Research Centre of Cardiology Named After Academician E.I. Chazov, 121552 Moscow, Russia.
Cells. 2025 Sep 12;14(18):1431. doi: 10.3390/cells14181431.
This study investigates the adrenal gland structure and gene expression in compared to , aiming to assess its relevance for human adrenal disease modeling. We identified a well-defined zona reticularis in , resembling the human adrenal cortex. Transcriptomic analysis revealed upregulation of key steroidogenic genes (C, , , , , ), with validation by qRT-PCR and CAGE-seq. The gene showed discordant results between RNA-seq and CAGE. Pathway analysis highlighted enrichment of steroidogenesis and adrenal metabolism. Notably, a GTEx-based comparison demonstrated that adrenal gene expression closely mirrors the expression in the human adrenal cortex, whereas samples diverged toward brain-specific signatures. These findings suggest that represents a promising model for adrenal research, though further studies including single-cell transcriptomics and functional assays are warranted to fully establish its translational potential.
本研究调查了[物种A]与[物种B]相比的肾上腺结构和基因表达，旨在评估其在人类肾上腺疾病建模中的相关性。我们在[物种A]中鉴定出了定义明确的网状带，类似于人类肾上腺皮质。转录组分析显示关键类固醇生成基因（C、[基因1]、[基因2]、[基因3]、[基因4]、[基因5]）上调，并通过qRT-PCR和CAGE-seq进行了验证。基因[基因6]在RNA-seq和CAGE之间显示出不一致的结果。通路分析突出了类固醇生成和肾上腺代谢的富集。值得注意的是，基于GTEx的比较表明，[物种A]的肾上腺基因表达与人类肾上腺皮质中的表达密切相似，而[物种B]样本则趋向于脑特异性特征。这些发现表明，[物种A]代表了肾上腺研究的一个有前景的模型，不过需要进一步开展包括单细胞转录组学和功能测定在内的研究，以充分确立其转化潜力。
