Joosen Renée S, Meulblok Eva A M, Mauritz-Fuite Esther H, Slieker Martijn G, Breur Johannes M P J
Department of Pediatric Cardiology, University Medical Center Utrecht, Lundlaan 6, 3584 EA Utrecht, The Netherlands.
J Cardiovasc Dev Dis. 2025 Aug 22;12(9):322. doi: 10.3390/jcdd12090322.
Right ventricular (RV) strain using two-dimensional speckle tracking is a reliable and clinically significant tool for detecting RV systolic dysfunction, but it varies by age, vendor, and software.
To establish pediatric age-specific normal values and Z-score equations for biventricular strain using GE Healthcare equipment and software.
Children 0-18 years with structurally and functionally normal hearts, who visited the Wilhelmina Children's Hospital Utrecht between October 2020 and December 2023, were retrospectively included and divided into age groups: 0 years, 1-4 years, 5-9 years, 10-13 years, and 14-18 years. Left ventricular (LV) and RV global longitudinal strain (GLS) and RV free wall longitudinal strain (FWGLS) were analyzed.
We included 129 subjects (57% male) (0 years: n = 17; 1-4 years: n = 22; 5-9 years: n = 34; 10-13 years: n = 35; 14-18 years: n = 20). Low R values were strain-adjusted for age, height, and body surface area (all < 0.3), and the sample size limited Z-score equation reliability. Therefore, data are presented as mean ± SD or median [IQR] stratified by age. LV GLS, RV GLS, and RV FWGLS showed a nonlinear relationship with age, peaking at the 1-4 years age group and decreasing with age.
LV GLS, RV GLS, and RV FWGLS showed age-related differences in children using GE equipment and software, which highlights the importance of age-specific normal strain values, including Z-score equations as a function of age.
使用二维斑点追踪技术测量的右心室（RV）应变是检测RV收缩功能障碍的一种可靠且具有临床意义的工具，但它会因年龄、设备供应商和软件的不同而有所变化。
使用通用电气医疗集团的设备和软件建立双心室应变的儿科特定年龄正常参考值和Z评分方程。
回顾性纳入2020年10月至2023年12月期间就诊于乌得勒支威廉明娜儿童医院、心脏结构和功能正常的0至18岁儿童，并将其分为以下年龄组：0岁、1至4岁、5至9岁、10至13岁和14至18岁。分析左心室（LV）和RV整体纵向应变（GLS）以及RV游离壁纵向应变（FWGLS）。
我们纳入了129名受试者（57%为男性）（0岁：n = 17；1至4岁：n = 22；5至9岁：n = 34；10至13岁：n = 35；14至18岁：n = 20）。对年龄、身高和体表面积进行应变校正后，相关系数R值较低（均<0.3），且样本量限制了Z评分方程的可靠性。因此，数据以按年龄分层的均值±标准差或中位数[四分位数间距]表示。LV GLS、RV GLS和RV FWGLS与年龄呈非线性关系，在1至4岁年龄组达到峰值，随后随年龄增长而下降。
使用通用电气设备和软件时，儿童的LV GLS、RV GLS和RV FWGLS存在年龄相关差异，这凸显了特定年龄正常应变值的重要性，包括作为年龄函数的Z评分方程。
