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神经源性吞咽困难:外周和中枢神经调节

Neurogenic Dysphagia: Peripheral and Central Neuromodulation.

作者信息

Stampanoni Bassi Mario, Centonze Diego, Gjikolaj Bledar, Alito Angelo, Tisano Adriana, Marchese-Ragona Rosario, Restivo Domenico Antonio

机构信息

Unit of Neurology, IRCCS Neuromed, 86077 Pozzilli, Italy.

Department of System Medicine, Tor Vergata University, 00133 Rome, Italy.

出版信息

Clin Pract. 2025 Sep 4;15(9):163. doi: 10.3390/clinpract15090163.

Abstract

Dysphagia is a frequent and potentially life-threatening complication in patients with neurological disorders. Swallowing is a complex neurophysiological mechanism regulated by a widespread network of central nervous system regions. The control of swallowing functions requires the integrity of the central pattern generator located in the brainstem, the sensorimotor cortex, the basal ganglia, and the cerebellum, but also peripheral nerves and swallowing muscles. Neurological diseases affecting either central or peripheral components of this system commonly result in dysphagia. Despite its clinical relevance, the management of neurogenic dysphagia remains challenging. While rehabilitative strategies such as swallowing therapy currently represent the main treatment option, emerging evidence suggests that non-invasive central and peripheral neuromodulation techniques may provide adjunctive beneficial effects. Further research is warranted to better define their efficacy, optimal protocols, and long-term outcomes.

摘要

吞咽困难是神经系统疾病患者常见且可能危及生命的并发症。吞咽是一种复杂的神经生理机制,受广泛的中枢神经系统区域网络调节。吞咽功能的控制不仅需要位于脑干、感觉运动皮层、基底神经节和小脑的中枢模式发生器的完整性,还需要周围神经和吞咽肌肉的完整性。影响该系统中枢或外周组成部分的神经疾病通常会导致吞咽困难。尽管其具有临床相关性,但神经源性吞咽困难的管理仍然具有挑战性。虽然吞咽治疗等康复策略目前是主要的治疗选择,但新出现的证据表明,非侵入性中枢和外周神经调节技术可能会带来辅助益处。有必要进行进一步研究,以更好地确定它们的疗效、最佳方案和长期结果。

本文引用的文献

7
An Overview Of The Management And Rehabilitation Of Dysphagia.吞咽困难的管理和康复概述。
J Pak Med Assoc. 2023 Aug;73(8):1749-1752. doi: 10.47391/JPMA.23-61.

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