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眩晕患者的脑结构异常、诊断方法及治疗策略:一项病例对照研究

Structural Brain Abnormalities, Diagnostic Approaches, and Treatment Strategies in Vertigo: A Case-Control Study.

作者信息

Széphelyi Klaudia, Kóra Szilvia, Orsi Gergely, Tollár József

机构信息

Doctoral School of Health Sciences, Faculty of Health Sciences, University of Pécs, 7622 Pécs, Hungary.

Faculty of Health Sciences and Social Studies, Department of Theoretical Health Sciences and Health Management, University of Szeged, 6726 Szeged, Hungary.

出版信息

Neurol Int. 2025 Sep 10;17(9):146. doi: 10.3390/neurolint17090146.

DOI:10.3390/neurolint17090146
PMID:41002934
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12472988/
Abstract

Dizziness is a frequent medical complaint with neurological, otolaryngological, and psychological origins. Imaging studies such as CT (Computer Tomography), cervical X-rays, and ultrasound aid diagnosis, while MRI (Magnetic Resonance Imaging) is crucial for detecting brain abnormalities. Our purpose is to identify structural brain changes associated with vertigo, assess pre-MRI diagnostic approaches, and evaluate treatment strategies. A case-control study of 232 vertigo patients and 232 controls analyzed MRI findings, pre-MRI examinations, symptoms, and treatments. Statistical comparisons were performed using chi-square and -tests ( < 0.05). : White matter lesions, lacunar infarcts, Circle of Willis variations, and sinusitis were significantly more frequent in vertigo patients ( < 0.05). Pre-MRI diagnostics frequently identified atherosclerosis (ultrasound) and spondylosis (X-ray). Common symptoms included headache, imbalance, and visual disturbances. The most frequent post-MRI diagnosis was Benign Paroxysmal Positional Vertigo (BPPV). Treatments included lifestyle modifications, physical therapy (e.g., Epley maneuver), and pharmacological therapies such as betahistine. : MRI revealed structural brain changes linked to vertigo. Pre-MRI assessments are essential for ruling out vascular and musculoskeletal causes. A multidisciplinary treatment approach is recommended. This study was registered in ClinicalTrials.gov with the trial registration number NCT06848712 on 22 February 2025.

摘要

头晕是一种常见的医学主诉,其病因涉及神经学、耳鼻喉科和心理学领域。诸如CT(计算机断层扫描)、颈椎X光片和超声等影像学检查有助于诊断,而MRI(磁共振成像)对于检测脑部异常至关重要。我们的目的是识别与眩晕相关的脑部结构变化,评估MRI检查前的诊断方法,并评估治疗策略。一项针对232名眩晕患者和232名对照者的病例对照研究分析了MRI检查结果、MRI检查前的各项检查、症状及治疗情况。采用卡方检验和t检验进行统计学比较(P<0.05)。结果显示:眩晕患者中白质病变、腔隙性脑梗死、 Willis环变异和鼻窦炎的发生率显著更高(P<0.05)。MRI检查前的诊断经常发现动脉粥样硬化(通过超声检查)和颈椎病(通过X光检查)。常见症状包括头痛、平衡失调和视觉障碍。MRI检查后最常见的诊断是良性阵发性位置性眩晕(BPPV)。治疗方法包括生活方式调整、物理治疗(如Epley手法)以及使用倍他司汀等药物治疗。结论:MRI显示了与眩晕相关的脑部结构变化。MRI检查前的评估对于排除血管和肌肉骨骼方面的病因至关重要。建议采用多学科治疗方法。本研究于2025年2月22日在ClinicalTrials.gov上注册,试验注册号为NCT06848712。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a72/12472988/95471219a5d5/neurolint-17-00146-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a72/12472988/b0e0d84ec30f/neurolint-17-00146-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a72/12472988/bfd143b533ea/neurolint-17-00146-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a72/12472988/e56f0d1cf5e4/neurolint-17-00146-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a72/12472988/68b742dfdd5f/neurolint-17-00146-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a72/12472988/95471219a5d5/neurolint-17-00146-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a72/12472988/b0e0d84ec30f/neurolint-17-00146-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a72/12472988/bfd143b533ea/neurolint-17-00146-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a72/12472988/e56f0d1cf5e4/neurolint-17-00146-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a72/12472988/68b742dfdd5f/neurolint-17-00146-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a72/12472988/95471219a5d5/neurolint-17-00146-g005.jpg

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本文引用的文献

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Altered cerebral gray matter volume and functional connectivity in patients with residual dizziness of benign paroxysmal positional vertigo.良性阵发性位置性眩晕残留头晕患者的脑灰质体积和功能连接改变
Clin Radiol. 2025 Mar;82:106780. doi: 10.1016/j.crad.2024.106780. Epub 2024 Dec 19.
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Imaging Outcomes of Emergency MR Imaging in Dizziness and Vertigo: A Retrospective Cohort Study.急诊磁共振成像在头晕和眩晕中的影像学结果:一项回顾性队列研究。
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Vestibular Schwannoma Presenting as Acute Vertigo Mimicking Vestibular Neuritis.
表现为酷似前庭神经炎的急性眩晕的前庭神经鞘瘤
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Diagnostic accuracy of neuroimaging in emergency department patients with acute vertigo or dizziness: A systematic review and meta-analysis for the guidelines for reasonable and appropriate care in the emergency department.急诊急性眩晕或头晕患者神经影像学诊断准确性的系统评价和荟萃分析:为急诊合理和适当护理制定的指南。
Acad Emerg Med. 2023 May;30(5):517-530. doi: 10.1111/acem.14561. Epub 2022 Aug 17.
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Orv Hetil. 2021 Nov 21;162(47):1891-1896. doi: 10.1556/650.2021.32271.
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Neuroimaging of Dizziness and Vertigo.头晕和眩晕的神经影像学
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Dizziness.头晕。
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Handb Clin Neurol. 2016;136:905-21. doi: 10.1016/B978-0-444-53486-6.00046-6.