Tulinski Maciej, Jurczyk Mieczyslawa U, Arkusz Katarzyna, Nowak Marek, Jurczyk Mieczyslaw
Institute of Materials Science and Engineering, Faculty of Materials Engineering and Technical Physics, Poznań University of Technology, Jana Pawla II 24, 61-138 Poznań, Poland.
Division of Mother's and Child's Health, Poznań University of Medical Sciences, Polna 33, 60-535 Poznań, Poland.
Nanomaterials (Basel). 2025 Sep 15;15(18):1417. doi: 10.3390/nano15181417.
Nanobiocomposites are a class of biomaterials that include at least one phase with constituents in the nanometer range. Nanobiocomposites, a new class of materials formed by combining natural and inorganic materials (metals, ceramics, polymers, and graphene) at the nanoscale dimension, are expected to revolutionize tissue engineering and bone implant applications because of their enhanced corrosion resistance, mechanical properties, biocompatibility, and antimicrobial activity. Titanium-based nanocomposites are gaining attention in biomedical applications due to their exceptional biocompatibility, corrosion resistance, and mechanical properties. These composites typically consist of a titanium or titanium alloy matrix that is embedded with nanoscale bioactive phases, such as hydroxyapatite, bioactive glass, polymers, or carbon-based nanomaterials. Common methods for synthesizing Ti-based nanobiocomposites and their parts, including bottom-up and top-down approaches, are presented and discussed. The synthesis conditions and appropriate functionalization influence the final properties of nanobiomaterials. By modifying the surface roughness at the nanoscale level, composite implants can be enhanced to improve tissue integration, leading to increased cell adhesion and protein adsorption. The objective of this review is to illustrate the most recent research on the synthesis and properties of Ti-based biocomposites and their scaffolds.
纳米生物复合材料是一类生物材料，其中至少有一个相的成分处于纳米范围内。纳米生物复合材料是通过在纳米尺度将天然材料与无机材料（金属、陶瓷、聚合物和石墨烯）结合而成的一类新型材料，由于其增强的耐腐蚀性、机械性能、生物相容性和抗菌活性，有望彻底改变组织工程和骨植入应用。基于钛的纳米复合材料因其卓越的生物相容性、耐腐蚀性和机械性能而在生物医学应用中受到关注。这些复合材料通常由嵌入纳米级生物活性相（如羟基磷灰石、生物活性玻璃、聚合物或碳基纳米材料）的钛或钛合金基体组成。介绍并讨论了合成钛基纳米生物复合材料及其部件的常用方法，包括自下而上和自上而下的方法。合成条件和适当的功能化会影响纳米生物材料的最终性能。通过在纳米尺度上改变表面粗糙度，可以增强复合植入物以改善组织整合，从而增加细胞粘附和蛋白质吸附。本综述的目的是阐述关于钛基生物复合材料及其支架的合成与性能的最新研究。
