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用于医学诊断的二氧化钛纳米管基传感器的进展:二十年回顾

Advancements in Titanium Dioxide Nanotube-Based Sensors for Medical Diagnostics: A Two-Decade Review.

作者信息

Sengupta Joydip, Hussain Chaudhery Mustansar

机构信息

Department of Electronic Science, Jogesh Chandra Chaudhuri College, Kolkata 700033, India.

Department of Chemistry and Environmental Science, New Jersey Institute of Technology, Newark, NJ 07102, USA.

出版信息

Nanomaterials (Basel). 2025 Jul 5;15(13):1044. doi: 10.3390/nano15131044.

DOI:10.3390/nano15131044
PMID:40648751
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12251031/
Abstract

Over the past two decades, titanium dioxide nanotubes (TiO NTs) have gained considerable attention as multifunctional materials in sensing technologies. Their large surface area, adjustable morphology, chemical stability, and photoactivity have positioned them as promising candidates for diverse sensor applications. This review presents a broad overview of the development of TiO NTs in sensing technologies for medical diagnostics over the last two decades. It further explores strategies for enhancing their sensing capabilities through structural modifications and hybridization with nanomaterials. Despite notable advancements, challenges such as device scalability, long-term operational stability, and fabrication reproducibility remain. This review outlines the evolution of TiO NT-based sensors for medical diagnostics, highlighting both foundational progress and emerging trends, while providing insights into future directions for their practical implementation across scientific and industrial domains.

摘要

在过去二十年中,二氧化钛纳米管(TiO NTs)作为传感技术中的多功能材料受到了广泛关注。它们具有大的表面积、可调节的形态、化学稳定性和光活性,使其成为各种传感器应用的有前途的候选材料。本文综述了过去二十年来TiO NTs在医学诊断传感技术中的发展概况。它进一步探讨了通过结构修饰和与纳米材料杂交来增强其传感能力的策略。尽管取得了显著进展,但仍存在诸如器件可扩展性、长期运行稳定性和制造再现性等挑战。本文概述了用于医学诊断的TiO NT基传感器的发展历程,突出了基础进展和新兴趋势,同时为其在科学和工业领域的实际应用提供了未来方向的见解。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d3c1/12251031/c8a4bd3347fc/nanomaterials-15-01044-sch003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d3c1/12251031/d3de8aec2b5f/nanomaterials-15-01044-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d3c1/12251031/cd505fae4027/nanomaterials-15-01044-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d3c1/12251031/65f0bf024549/nanomaterials-15-01044-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d3c1/12251031/51070b08008b/nanomaterials-15-01044-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d3c1/12251031/cb4c8fc533b8/nanomaterials-15-01044-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d3c1/12251031/4f16d53eb281/nanomaterials-15-01044-sch001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d3c1/12251031/4a853d998162/nanomaterials-15-01044-sch002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d3c1/12251031/c8a4bd3347fc/nanomaterials-15-01044-sch003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d3c1/12251031/d3de8aec2b5f/nanomaterials-15-01044-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d3c1/12251031/cd505fae4027/nanomaterials-15-01044-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d3c1/12251031/65f0bf024549/nanomaterials-15-01044-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d3c1/12251031/51070b08008b/nanomaterials-15-01044-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d3c1/12251031/cb4c8fc533b8/nanomaterials-15-01044-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d3c1/12251031/4f16d53eb281/nanomaterials-15-01044-sch001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d3c1/12251031/4a853d998162/nanomaterials-15-01044-sch002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d3c1/12251031/c8a4bd3347fc/nanomaterials-15-01044-sch003.jpg

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本文引用的文献

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Biosensors (Basel). 2025 May 7;15(5):296. doi: 10.3390/bios15050296.
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Aptamer and Oligonucleotide-Based Biosensors for Health Applications.用于健康应用的适配体和基于寡核苷酸的生物传感器。
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Fabrication of TiO Nanotube Arrays by Progressive Anodization of Ti Thin Film on Insulated Substrates.
通过在绝缘衬底上对钛薄膜进行逐步阳极氧化制备TiO纳米管阵列。
Materials (Basel). 2025 Mar 9;18(6):1219. doi: 10.3390/ma18061219.
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A novel electrochemical biosensor based on TiO nanotube array films for highly sensitive detection of exosomes.一种基于TiO纳米管阵列薄膜的新型电化学生物传感器,用于高灵敏度检测外泌体。
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Recent Advances in Preparation, Modification, and Application of Free-Standing and Flow-Through Anodic TiO Nanotube Membranes.自支撑及流通式阳极TiO纳米管膜的制备、改性与应用研究进展
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