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早期硬膜外镇痛用于疑似自发性嗜铬细胞瘤破裂的术前管理:一例报告

Early epidural analgesia for the preoperative management of suspected spontaneous pheochromocytoma rupture: a case report.

作者信息

Oshiba Yukina, Shibata Sho C, Lee Taehun, Inoue Junichi, Kita Takashi

机构信息

Department of Anesthesiology and Intensive Care Medicine, Osaka University Graduate School of Medicine, Suita, Japan.

Department of Anesthesiology, Osaka International Medical & Science Center, Osaka, Japan.

出版信息

JA Clin Rep. 2025 Sep 26;11(1):49. doi: 10.1186/s40981-025-00813-9.

Abstract

BACKGROUND

Acute abdominal pain is an uncommon manifestation of pheochromocytoma. Poor pain management may delay preoperative optimization of hemodynamics and intravascular blood volume. We report a case in which early epidural analgesia facilitated preoperative preparation for a laparoscopic adrenalectomy.

CASE PRESENTATION

A female patient diagnosed with pheochromocytoma developed the sudden onset of severe left lower abdominal pain, hypertension, nausea, and vomiting. Pain treatment with acetaminophen and loxoprofen was insufficient, and opioids were avoided due to persistent nausea and constipation. Initiation of continuous thoracic epidural analgesia with 0.25% levobupivacaine resulted in rapid pain relief and improved gastrointestinal symptoms. Over a 9-day period, blood pressure and intravascular blood volume were optimized while epidural analgesia was continued. She underwent a successful adrenalectomy and was discharged without complications.

CONCLUSIONS

This case illustrates the potential utility of early epidural analgesia in the preoperative management of pheochromocytoma, particularly in patients with refractory abdominal pain and limited opioid tolerance.

摘要

背景

急性腹痛是嗜铬细胞瘤的一种罕见表现。疼痛管理不善可能会延迟术前血流动力学和血管内容量的优化。我们报告一例早期硬膜外镇痛有助于腹腔镜肾上腺切除术术前准备的病例。

病例介绍

一名被诊断为嗜铬细胞瘤的女性患者突然出现严重的左下腹痛、高血压、恶心和呕吐。对乙酰氨基酚和洛索洛芬的止痛治疗效果不佳,由于持续恶心和便秘,未使用阿片类药物。使用0.25%左旋布比卡因开始持续胸段硬膜外镇痛后,疼痛迅速缓解,胃肠道症状改善。在9天的时间里,在持续硬膜外镇痛的同时优化了血压和血管内容量。她成功接受了肾上腺切除术,出院时无并发症。

结论

本病例说明了早期硬膜外镇痛在嗜铬细胞瘤术前管理中的潜在作用,特别是对于难治性腹痛和阿片类药物耐受性有限的患者。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b3c9/12474838/5b578cf65eca/40981_2025_813_Fig1_HTML.jpg

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