Josa-Culleré Alícia, Cakmak-Onal Aslihan, Gimeno-Santos Elena, Alcaraz-Serrano Victoria, Buekers Joren, Delgado-Ortiz Laura, Marin Alicia, Rodríguez-Chiaradia Diego A, Garcia-Aymerich Judith, Rivas Ioar, Koch Sarah
ISGlobal, Barcelona, Spain.
Universitat Pompeu Fabra (UPF), Barcelona, Spain.
Eur Respir Rev. 2025 Sep 26;34(177). doi: 10.1183/16000617.0042-2025. Print 2025 Jul.
The inhaled dose of air pollution (IDoAP) is an air pollution exposure quantification method that accounts for individuals' amount of inspired air ( minute ventilation), and thus for the physical activity practised by individuals. We aimed to summarise the existing literature and identify research gaps on the health effects of IDoAP.We included original peer-reviewed research in PubMed, Scopus, SPORTDiscus, Embase and Cochrane prior to November 2024 and appraised bias following Cochrane and ROBINS-E tools. Title, abstract and full-text screening, data extraction and bias appraisal were completed in duplicate.Of 1888 screened studies, 25 studies were included, mostly focusing on healthy adults (21 out of 25 studies), overlooking susceptible populations such as pregnant individuals or those with pre-existing disease. Studies focused primarily on IDoAP of O (IDoAP-O) (14 out of 25 studies) and particulate matter <2.5 µm in aerodynamic diameter (IDoAP-PM) (13 out of 25 studies), with an exposure duration of up to 24 h. Lung function was the most studied outcome (19 out of 25 studies). Acute exposure to IDoAP-O was associated with reduced lung function: increasing IDoAP-O by 150 μg·m led to a decrease in forced expiratory volume in 1 s (FEV) of 0.27 L. This was driven by O concentration, while increases in minute ventilation did not affect FEV A number of research gaps were identified. These comprised research on susceptible and vulnerable populations, including residents of low-to-middle-income regions, and people with extreme occupational exposures; air pollutants other than O and PM; and outcomes besides respiratory markers. Alternative statistical approaches are also required, such as multi-exposure models.Our findings support initiatives to generate low-pollution public corridors to keep IDoAP levels as low as possible to maximise health benefits from physical activity.
吸入空气污染剂量（IDoAP）是一种空气污染暴露量化方法，该方法考虑了个体的吸入空气量（分钟通气量），进而考虑了个体所进行的身体活动。我们旨在总结现有文献并确定关于IDoAP对健康影响的研究空白。我们纳入了2024年11月之前发表在PubMed、Scopus、SPORTDiscus、Embase和Cochrane上的经同行评审的原创研究，并根据Cochrane和ROBINS-E工具评估偏倚。标题、摘要和全文筛选、数据提取和偏倚评估均进行了重复操作。在1888项筛选研究中，纳入了25项研究，这些研究大多聚焦于健康成年人（25项研究中有21项），而忽略了易感人群，如孕妇或患有基础疾病的人群。研究主要集中在臭氧的IDoAP（IDoAP-O）（25项研究中有14项）和空气动力学直径小于2.5微米的颗粒物的IDoAP（IDoAP-PM）（25项研究中有13项），暴露持续时间长达24小时。肺功能是研究最多的结局（25项研究中有19项）。急性暴露于IDoAP-O与肺功能下降有关：IDoAP-O每增加150μg·m，1秒用力呼气量（FEV）就会减少0.27L。这是由臭氧浓度驱动的，而分钟通气量的增加并未影响FEV。确定了一些研究空白。这些空白包括对易感和脆弱人群的研究，包括低收入和中等收入地区的居民以及职业暴露极端的人群；除臭氧和颗粒物之外的空气污染物；以及除呼吸标志物之外的结局。还需要替代统计方法，如多暴露模型。我们的研究结果支持采取措施创建低污染公共通道，以使IDoAP水平尽可能低，从而使身体活动带来的健康益处最大化。
