Saps Miguel, Arrizabalo Samantha, Garza Jose M
Department of Pediatrics, Division of Gastroenterology, Hepatology and Nutrition, Miller School of Medicine, University of Miami, Miami, FL 33136, USA.
Children's Center for Digestive Health Care, Children's Healthcare of Atlanta, Atlanta, GA 30342, USA.
Children (Basel). 2025 Sep 10;12(9):1209. doi: 10.3390/children12091209.
Disorders of gut-brain interaction (DGBI) have a significant impact on the quality of life of children and families. Forty percent of children with recurrent abdominal pain continue to have symptoms into adulthood. Specialized programs for the transition of adolescents with DGBI to adult care are scarce. There are no widely accepted guidelines for transition of care. Identifying risk factors for persistence of symptoms into adulthood is key to identifying the optimal population that should be part of such programs and guidelines design.
A narrative comprehensive review was conducted using predefined keywords to identify risk factors for persistent DGBI in children/adolescents.
Female sex, psychological distress, family history of DGBI, and certain comorbidities had stronger evidence for persistence, whereas other risk factors rely on limited data.
It is suggested that transition programs should focus on adolescents presenting with multiple coexisting risk factors. The program should at least include pediatric and adult neurogastroenterologists, dieticians, psychologists, and social workers. Tertiary prevention through psychological support, school-based programs, and management of anxiety and sleep disturbances may reduce the persistence of symptoms. Prospective studies should refine risk stratification and guide transition strategies.
肠-脑互动障碍（DGBI）对儿童及其家庭的生活质量有重大影响。40%的复发性腹痛儿童成年后仍有症状。针对患有DGBI的青少年向成人护理过渡的专门项目很少。目前尚无被广泛接受的护理过渡指南。识别症状持续至成年期的风险因素是确定此类项目和指南设计应涵盖的最佳人群的关键。
使用预定义关键词进行叙述性综合综述，以识别儿童/青少年持续性DGBI的风险因素。
女性、心理困扰、DGBI家族史和某些合并症有更强的证据表明症状会持续，而其他风险因素的数据有限。
建议过渡项目应关注存在多种共存风险因素的青少年。该项目至少应包括儿科和成人神经胃肠病学家、营养师、心理学家和社会工作者。通过心理支持、校本项目以及焦虑和睡眠障碍管理进行三级预防可能会减少症状的持续。前瞻性研究应完善风险分层并指导过渡策略。
