Simac Petra, Petric Marin, Jankovic Danolic Marijana, Perković Dijana
Division of Rheumatology and Clinical Immunology, Department of Internal Medicine, University Hospital of Split, 21000 Split, Croatia.
School of Medicine, University of Split, 21000 Split, Croatia.
Biomedicines. 2025 Sep 19;13(9):2300. doi: 10.3390/biomedicines13092300.
Adropin is a regulatory peptide hormone involved in metabolic homeostasis, cardiovascular protection, and immune modulation. Recent evidence suggests that adropin plays a role in the pathophysiology of autoimmune rheumatic diseases (ARDs) by influencing key processes such as endothelial function, oxidative stress, tissue fibrosis, and immune cell regulation. This review summarizes current knowledge on adropin's biological functions and its relevance in conditions including rheumatoid arthritis, systemic lupus erythematosus, systemic sclerosis, primary Sjögren's syndrome, osteoarthritis, psoriasis, Behçet's disease, and Kawasaki disease. We discuss how adropin interacts with various signaling pathways and highlight its potential role in macrophage polarization, regulatory T cell activity, and fibrotic remodeling. Although data remain limited and sometimes conflicting, altered adropin levels have been observed across several ARDs, suggesting potential utility as a biomarker or therapeutic target. Further research is needed to clarify its clinical significance and translational potential in immune-mediated diseases.
内脂素是一种参与代谢稳态、心血管保护和免疫调节的调节肽激素。最近的证据表明，内脂素通过影响内皮功能、氧化应激、组织纤维化和免疫细胞调节等关键过程，在自身免疫性风湿病（ARDs）的病理生理学中发挥作用。这篇综述总结了目前关于内脂素生物学功能及其在类风湿关节炎、系统性红斑狼疮、系统性硬化症、原发性干燥综合征、骨关节炎、银屑病、白塞病和川崎病等疾病中的相关性的知识。我们讨论了内脂素如何与各种信号通路相互作用，并强调了其在巨噬细胞极化、调节性T细胞活性和纤维化重塑中的潜在作用。尽管数据仍然有限且有时相互矛盾，但在几种ARDs中都观察到了内脂素水平的改变，这表明它作为生物标志物或治疗靶点具有潜在的应用价值。需要进一步的研究来阐明其在免疫介导疾病中的临床意义和转化潜力。
