Central Laboratory, The First Affiliated Hospital of Hebei North University, Zhangjiakou, China.
Department of Immunology, School of Basic Medical Sciences, Fujian Medical University, Fuzhou, China.
Front Immunol. 2022 Jun 9;13:908749. doi: 10.3389/fimmu.2022.908749. eCollection 2022.
Macrophages are a population of immune cells functioning in antigen presentation and inflammatory response. Research has demonstrated that macrophages belong to a cell lineage with strong plasticity and heterogeneity and can be polarized into different phenotypes under different microenvironments or stimuli. Many macrophages can be recruited by various cytokines secreted by adipose tissue. The recruited macrophages further secrete various inflammatory factors to act on adipocytes, and the interaction between the two leads to chronic inflammation. Previous studies have indicated that adipose tissue macrophages (ATMs) are closely related to metabolic diseases like obesity and diabetes. Here, we will not only conclude the current progress of factors affecting the polarization of adipose tissue macrophages but also elucidate the relationship between ATMs and human diseases. Furthermore, we will highlight its potential in preventing and treating metabolic diseases as immunotherapy targets.
巨噬细胞是一类在抗原呈递和炎症反应中发挥作用的免疫细胞。研究表明，巨噬细胞属于具有强大可塑性和异质性的细胞谱系，在不同的微环境或刺激下可以极化为不同的表型。许多巨噬细胞可以被脂肪组织分泌的各种细胞因子募集。募集的巨噬细胞进一步分泌各种炎症因子作用于脂肪细胞，两者相互作用导致慢性炎症。先前的研究表明，脂肪组织巨噬细胞（ATMs）与肥胖和糖尿病等代谢疾病密切相关。在这里，我们不仅将总结影响脂肪组织巨噬细胞极化的因素的最新进展，还将阐明 ATMs 与人类疾病的关系。此外，我们将强调其作为免疫治疗靶点预防和治疗代谢性疾病的潜力。
