Yilmaz Zeki, Salci Hakan, Levent Pınar, Algan Didem, Varlik Tuğba, Topçu Mehmet Emre, Tanaka Ryou, Hamabe Lina
Department of Internal Medicine, Veterinary Faculty, Bursa Uludag University, 16059 Bursa, Turkey.
Department of Surgery, Veterinary Faculty, Bursa Uludag University, 16059 Bursa, Turkey.
Animals (Basel). 2025 Sep 12;15(18):2674. doi: 10.3390/ani15182674.
Cardiac tumors are rare and linked to high mortality rates in both human and veterinary medicine. Despite their clinical significance, the effects of these tumors on coagulation and cardiac function remain poorly understood. This retrospective study assessed coagulation profiles and echocardiographic parameters in 14 dogs with cardiac tumors compared to 10 healthy controls. Tumors were identified through echocardiography, with further confirmation by computed tomography/magnetic resonance imaging. Coagulation was evaluated using conventional tests (prothrombin time (PT) and activated partial thromboplastin time (aPTT)) and thromboelastography (TEG). The employed conventional coagulation tests and echocardiographic parameters showed no significant differences between the groups. However, TEG revealed a hypercoagulable state in the majority of tumor-bearing dogs (8 out of 14), characterized by shortened reaction and clot formation times, as well as an increased α-angle and coagulation index ( < 0.05-0.001). No significant correlations were found between TEG parameters and echocardiographic indices. This study is the first to demonstrate subclinical hemostatic alterations using TEG in dogs with cardiac neoplasia. The results support the utility of TEG as a more sensitive tool than conventional tests for detecting hypercoagulability, potentially guiding individualized anticoagulant strategies in affected dogs.
心脏肿瘤在人和兽医学中都很罕见，且与高死亡率相关。尽管其具有临床意义，但这些肿瘤对凝血和心脏功能的影响仍知之甚少。这项回顾性研究评估了14只患有心脏肿瘤的犬与10只健康对照犬的凝血指标和超声心动图参数。通过超声心动图识别肿瘤，并通过计算机断层扫描/磁共振成像进一步确认。使用传统检测方法（凝血酶原时间（PT）和活化部分凝血活酶时间（aPTT））和血栓弹力图（TEG）评估凝血情况。所采用的传统凝血检测方法和超声心动图参数在两组之间没有显著差异。然而，TEG显示大多数患肿瘤犬（14只中的8只）处于高凝状态，其特征为反应时间和凝块形成时间缩短，以及α角和凝血指数增加（<0.05 - 0.001）。在TEG参数和超声心动图指标之间未发现显著相关性。本研究首次证明在患有心脏肿瘤的犬中使用TEG可检测到亚临床止血改变。结果支持TEG作为一种比传统检测方法更敏感的工具用于检测高凝状态，可能为受影响犬只指导个体化抗凝策略。
