Reproductive Effects of Endocrine Disruptors in Domestic Ruminants: Integrating In Vitro and In Vivo Evidence.

Endocrine-disrupting chemicals (EDCs) have raised increasing concern due to their potential effects on reproductive health. This review focuses on the impact of EDCs, particularly bisphenol A (BPA) and its analogues, and per- and polyfluoroalkyl substances (PFAS), on domestic ruminants (cattle and sheep) by integrating findings from both in vitro and in vivo studies. The analysis highlights how exposure to EDCs affects steroidogenesis, oxidative stress responses, apoptosis, epigenetic regulation, and overall fertility markers, such as oocyte maturation, sperm motility, and embryo developmental competence. While most data originate from in vitro bovine studies, in vivo research in sheep offers valuable insights. Importantly, given the potential for EDCs to bioaccumulate in animal tissues, these findings hold significant implications for animal health, particularly regarding reproductive physiology and fertility rates.