Kazantzis Dimitrios, Machairoudia Genovefa, Theodossiadis Panagiotis, Chatziralli Irini
2nd Department of Ophthalmology, National and Kapodistrian University of Athens, Attikon University Hospital, 12462 Athens, Greece.
Moorfields Eye Hospital NHS Foundation Trust, London EC1V 2PD, UK.
Diagnostics (Basel). 2025 Sep 19;15(18):2394. doi: 10.3390/diagnostics15182394.
: This study aimed to investigate changes and synthesize the existing evidence in macular choroidal thickness in patients with keratoconus (KC) compared to healthy controls, utilizing optical coherence tomography (OCT). : PubMed and Scopus databases were systematically searched for published articles comparing choroidal thickness between patients with KC and healthy controls. The Mean Difference (MD) with 95% confidence interval (CI) was computed to compare continuous variables. Our study was registered with PROSPERO with registration ID: CRD42024605227. Revman 5.4 was used for the analysis. 10 studies were included in the analysis. Subfoveal choroidal thickness was increased in patients with KC compared to controls. (MD = 43.94, 95% CI = 17.36-70.51, = 0.001, I = 95%). Leave-one-out sensitivity analysis confirmed this finding. : Our meta-analysis demonstrated that eyes with keratoconus have significantly increased macular choroidal thickness compared to controls. These findings highlight the need for longitudinal studies stratified by disease severity to clarify the role of choroidal changes in keratoconus progression.
本研究旨在利用光学相干断层扫描（OCT），调查圆锥角膜（KC）患者与健康对照者相比黄斑脉络膜厚度的变化并综合现有证据。通过系统检索PubMed和Scopus数据库，查找比较KC患者与健康对照者脉络膜厚度的已发表文章。计算95%置信区间（CI）的平均差（MD）以比较连续变量。我们的研究已在PROSPERO注册，注册号为：CRD42024605227。使用Revman 5.4进行分析。分析纳入了10项研究。与对照组相比，KC患者的黄斑中心凹下脉络膜厚度增加。（MD = 43.94，95% CI = 17.36 - 70.51，P = 0.001，I² = 95%）。留一法敏感性分析证实了这一发现。我们的荟萃分析表明，与对照组相比，圆锥角膜患者的黄斑脉络膜厚度显著增加。这些发现凸显了有必要开展按疾病严重程度分层的纵向研究，以阐明脉络膜变化在圆锥角膜进展中的作用。
