Correlates of Loneliness in Parkinson Disease During the COVID-19 Pandemic: A Longitudinal Study.

Parkinson disease (PD) patients are particularly vulnerable to the effects of loneliness. The objective of this longitudinal study was to assess how the COVID-19 pandemic affected loneliness in PD patients by identifying the correlates of loneliness during the pandemic in the US and to establish a rationale for providing emotional support and restoring morale. Consecutive PD outpatients were recruited during June 2016-May 2017. Data on sociodemographic, clinical, and psychological variables were obtained. During October-December 2020, participants were mailed a questionnaire about some of the variables studied at baseline and new variables specifically related to the pandemic. Univariate, bivariate, and forward linear regression analyses were used to identify the correlates of loneliness. Sex, demoralization, and baseline PD health-related quality of life were significantly associated with loneliness during COVID-19 pandemic, with women reporting more loneliness than men. To examine loneliness specifically associated with the COVID-19 pandemic, loneliness prior to the pandemic was controlled, with only sex and demoralization remaining statistically significant. Interventions aimed at restoring morale and providing emotional support should be included as an essential component of any treatment plan designed to alleviate loneliness during public health emergencies that require social isolation, such as a pandemic.