Lupia Tommaso, Sarda Cristina, Canta Francesca, Casarotto Marco, Accardo Guido, Roccuzzo Gabriele, Macagno Nicole, Gelato Federica, Senetta Rebecca, Ottobrelli Antonio, De Rosa Francesco Giuseppe, Corcione Silvia, Ribero Simone, Quaglino Pietro, Fava Paolo
Unit of Infectious Diseases, City of Health and Sciences, 10100 Turin, Italy.
Dermatology Clinic, Section of Dermatology, Department of Medical Sciences, University of Turin, 10100 Turin, Italy.
Life (Basel). 2025 Sep 17;15(9):1453. doi: 10.3390/life15091453.
() is an emerging filamentous fungus known to cause opportunistic infections, particularly in immunocompromised patients. Formerly known as , this pathogen is widespread in the environment and can lead to a range of infections, from superficial skin lesions to invasive diseases. This article presents a case of deep cutaneous hyalohyphomycosis caused by in a liver transplant patient, followed by a review of the literature focusing on new antifungal agents.
We reported a brief case description followed by a narrative review of the literature regarding cutaneous and lymphangitic infections in immunocompromised patients.
We conducted a review of the literature over the past 20 years, focusing on the clinical features, diagnostic challenges, and therapeutic outcomes of cutaneous and lymphangitic infections in immunocompromised hosts.
This review highlights the critical importance of early diagnosis through the analysis of biopsy samples using standard microbiological and histological techniques, complemented by innovative molecular biology methods. We also emphasise the role of appropriate antifungal treatment, despite the absence of an established standard of care, particularly in high-risk patients. Furthermore, we review and discuss the current lack of a standardised therapeutic regimen and the potential of novel antifungal agents as promising treatment options for infections.
（）是一种新兴的丝状真菌，已知可引起机会性感染，尤其是在免疫功能低下的患者中。该病原体以前称为，在环境中广泛存在，可导致一系列感染，从浅表皮肤病变到侵袭性疾病。本文介绍了一例肝移植患者由（）引起的深部皮肤透明丝孢霉病病例，随后对侧重于新型抗真菌药物的文献进行了综述。
我们报告了一个简短的病例描述，随后对关于免疫功能低下患者（）皮肤和淋巴管感染的文献进行了叙述性综述。
我们对过去20年的文献进行了综述，重点关注免疫功能低下宿主中（）皮肤和淋巴管感染的临床特征、诊断挑战和治疗结果。
本综述强调了通过使用标准微生物学和组织学技术分析活检样本，并辅以创新的分子生物学方法进行早期诊断的至关重要性。我们还强调了适当抗真菌治疗的作用，尽管缺乏既定的护理标准，特别是在高危患者中。此外，我们回顾并讨论了目前缺乏标准化治疗方案以及新型抗真菌药物作为（）感染有前景的治疗选择的潜力。
