Profili Nicia I, Fiorillo Edoardo, Marongiu Michele, Cucca Francesco, Delitala Alessandro P
Department of Medicine, Surgery, and Pharmacy, University of Sassari, 07100 Sassari, Italy.
Institute for Genetic and Biomedical Research, National Research Council, 08045 Lanusei, Italy.
J Clin Med. 2025 Sep 18;14(18):6580. doi: 10.3390/jcm14186580.
: Blood pressure is associated with overt thyroid disorders, but the role of subclinical diseases is not clear, particularly when blood pressure is assessed at the clinical office. Ambulatory blood pressure monitoring over 24 h provides additional clinical information, which correlates with many cardiovascular endpoints. The aim of our work is to examine whether thyroid function is related to systolic and diastolic blood pressure assessed by ambulatory blood pressure monitoring. : We enrolled 3277 subjects from the SardiNIA project. Thyroid function and ambulatory blood pressure monitoring were assessed in all the participants. : TSH was associated with average 24 h and daytime DBP in males but not in females, after adjusting for confounders (respectively, Coef -0.192 = 0.025, and Coef. -0.021, = 0.018). We found no association between TSH and DBP or SBP during nighttime. : Low TSH in males is positively associated with high DBP. Further studies of underlying mechanisms will need to explore our findings.
血压与显性甲状腺疾病有关，但亚临床疾病的作用尚不清楚，尤其是在临床诊室评估血压时。24小时动态血压监测可提供额外的临床信息，这与许多心血管终点相关。我们研究的目的是检验甲状腺功能是否与通过动态血压监测评估的收缩压和舒张压相关。
我们从撒丁岛项目中招募了3277名受试者。对所有参与者进行了甲状腺功能和动态血压监测。
在调整混杂因素后，促甲状腺激素（TSH）与男性24小时平均舒张压及日间舒张压相关，但与女性无关（系数分别为-0.192，P = 0.025，以及系数-0.021，P = 0.018）。我们发现夜间TSH与舒张压或收缩压之间无关联。
男性低TSH与高舒张压呈正相关。对潜在机制的进一步研究需要探索我们的发现。
