Iorga Polixenia Georgeta, Dragomirescu Andreea, Scurtu Lucian G, Simionescu Olga
Faculty of Medicine, "Carol Davila" University of Medicine and Pharmacy, 020021 Bucharest, Romania.
Department of Medical Oncology, Bucharest Emergency University Hospital, 011461 Bucharest, Romania.
Medicina (Kaunas). 2025 Aug 31;61(9):1570. doi: 10.3390/medicina61091570.
Skin metastases represent a rare finding in dermatological practice, but their presence signifies an advanced disease and usually portends a poor prognosis. They commonly arise as multiple painless nodules in patients with a cancer history. Differential diagnoses are challenging, and zosteriform metastases should not be mistaken for herpes zoster. Dermoscopy typically reveals a white, structureless pattern. A skin biopsy with routine hematoxylin-eosin staining is essential for an accurate diagnosis, while immunohistochemistry is particularly useful in cases of anaplastic tumors. Breast cancer is the most common cause of skin metastasis in women, and lung cancer is the most common in men. The life expectancy after diagnosis is generally low. Cutaneous metastasectomy, electrochemotherapy, and radiotherapy are generally regarded as beneficial for palliative purposes. Intralesional cryosurgery was found to be beneficial in a few case series. Systemic immunotherapy can induce the regression of cutaneous metastases in selected patients.
皮肤转移瘤在皮肤科临床实践中较为罕见，但其出现表明疾病已进展至晚期，通常预示预后不良。它们常见于有癌症病史的患者，表现为多个无痛性结节。鉴别诊断具有挑战性，带状转移不应误诊为带状疱疹。皮肤镜检查通常显示白色、无结构的模式。进行常规苏木精 - 伊红染色的皮肤活检对于准确诊断至关重要，而免疫组化在间变性肿瘤病例中特别有用。乳腺癌是女性皮肤转移最常见的原因，肺癌是男性中最常见的。诊断后的预期寿命通常较低。皮肤转移瘤切除术、电化学疗法和放射疗法一般被认为对缓解症状有益。在一些病例系列中发现皮损内冷冻手术是有益的。全身免疫疗法可使部分患者的皮肤转移瘤消退。
