Ordak Michal, Gorecka Wiktoria, Konieczynski Pawel, Wesolowski Marek, Plenis Alina, Tadeusz Nasierowski, Magdalena Bujalska-Zadrozny
Department of Pharmacotherapy and Pharmaceutical Care, Faculty of Pharmacy, Medical University of Warsaw, Banacha 1 Str., 02-097 Warsaw, Poland.
Department of Analytical Chemistry, Faculty of Pharmacy, Medical University of Gdansk, Gen. J. Hallera 107, 80-416 Gdansk, Poland.
Toxics. 2025 Aug 30;13(9):734. doi: 10.3390/toxics13090734.
In recent years, the consumption of has gained popularity as a perceived natural alternative to psychoactive substances, often promoted online for its supposed therapeutic properties. However, the safety of such preparations remains largely unverified, particularly with regard to toxic element content. The present study focused on evaluating how different preparation methods affect the concentrations of cadmium (Cd) and lead (Pb) in the most commonly consumed products. A total of 50 mushroom caps were collected in October 2024 from the Stąporków Forest District in central Poland. Seven types of preparations were analyzed: dried with skin, dried without skin, tincture (mineralized and direct), boiled, fermented, infusion, and decoction. Samples were analyzed using atomic absorption spectrometry (AAS); depending on the preparation type, some underwent acid digestion prior to measurement. Statistically significant differences in lead concentrations were observed between the various preparation types ( = 0.002; η = 0.97). Lead levels in the direct tincture were significantly higher than those in the boiled ( = 0.001), infusion ( = 0.001), decoction ( = 0.009), and dried without skin ( = 0.04) forms. Significant differences in cadmium concentrations were also found ( = 0.006; η = 0.94), with lower Cd levels in the decoction compared to the dried with skin ( = 0.009) and without skin ( = 0.001), as well as in the fermented form compared to the dried samples ( = 0.03 and = 0.004, respectively). These findings demonstrate that the type of preparation significantly influences the levels of cadmium and lead in products. While aqueous and fermented preparations showed reduced metal concentrations, none can be considered entirely safe, as even lower levels of Cd and Pb may pose health risks with frequent or excessive consumption.
近年来,[某种物质]的消费作为一种被认为是精神活性物质的天然替代品而受到欢迎,其所谓的治疗特性经常在网上得到宣传。然而,这类制剂的安全性在很大程度上仍未得到验证,尤其是在有毒元素含量方面。本研究的重点是评估不同的制备方法如何影响最常食用的[某种物质]产品中镉(Cd)和铅(Pb)的浓度。2024年10月,从波兰中部的斯塔普科夫森林区共采集了50个蘑菇帽。分析了七种类型的制剂:带皮干燥、去皮干燥、酊剂(矿化和直接提取)、水煮、发酵、浸泡和煎剂。使用原子吸收光谱法(AAS)对样品进行分析;根据制剂类型的不同,一些样品在测量前进行了酸消解。在各种制剂类型之间观察到铅浓度存在统计学上的显著差异(P = 0.002;η = 0.97)。直接提取的酊剂中的铅含量显著高于水煮(P = 0.001)、浸泡(P = 0.001)、煎剂(P = 0.009)和去皮干燥(P = 0.04)形式的铅含量。镉浓度也发现了显著差异(P = 0.006;η = 0.94),煎剂中的镉含量低于带皮干燥(P = 0.009)和去皮干燥(P = 0.001)的样品,发酵形式的镉含量低于干燥样品(分别为P = 0.03和P = 0.004)。这些发现表明,制剂类型对[某种物质]产品中的镉和铅含量有显著影响。虽然水性和发酵制剂显示金属浓度降低,但没有一种可以被认为是完全安全的,因为即使是较低水平的镉和铅,频繁或过量食用也可能对健康构成风险。