Ali Khaled M, Mostafa Ayman A
Department of Small Animal Surgery and Ophthalmology, Faculty of Veterinary Medicine, Cairo University, Giza 12613, Egypt.
Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Western University of Health Sciences, Pomona, CA 91766, USA.
Vet Sci. 2025 Aug 30;12(9):839. doi: 10.3390/vetsci12090839.
Corneal sequestrum, also known as corneal mummification or necrosis, is a common complication of corneal ulceration in cats, with brachycephalic and pure-bred cats being the most affected. This prospective clinical trial aimed to evaluate the efficacy of self-adhesive, human bandage contact lenses (SHBCLs) versus the commonly used conjunctival transposition flap (CTF) in the management of feline corneal sequestrum. Twenty-five client-owned cats of different breeds with unilateral corneal sequestrum were investigated. All cats underwent a complete ophthalmic examination. Characterization of corneal sequestrum was carried out. The corneal lesion was removed surgically via keratectomy, and the cats were then categorized into three treatment groups: G-SHBCL (10 cats), G-CTF (10 cats), and the control group (G-CO, 5 cats). The healing progress of the corneal defect and associated clinical findings were recorded in all studied groups. Eight out of ten cats (80%) treated with SBCLs showed complete healing of the corneal defect with light corneal scarring and absence of all signs of ocular pain or discomfort. In comparison with G-CTF and G-CO, no granulation tissue was observed in all cats treated with SHBCLs. Moreover, no residues of corneal sequestrum or adhesion were identified, and the degree of corneal clarity was higher in the SHBCL treatment group. In conclusion, application of SHBCLs on a corneal defect, after removal of the associated sequestrum, enhances healing of the cornea and markedly improves the corneal clarity and transparency within a short period.
角膜干尸化,也称为角膜木乃伊化或坏死,是猫角膜溃疡的常见并发症,短头猫和纯种猫受影响最大。这项前瞻性临床试验旨在评估自粘性人用绷带隐形眼镜(SHBCL)与常用的结膜转位瓣(CTF)在治疗猫角膜干尸化中的疗效。对25只不同品种的单侧角膜干尸化的客户拥有的猫进行了研究。所有猫都接受了全面的眼科检查。对角膜干尸化进行了特征描述。通过角膜切除术手术切除角膜病变,然后将猫分为三个治疗组:G-SHBCL组(10只猫)、G-CTF组(10只猫)和对照组(G-CO组,5只猫)。记录所有研究组角膜缺损的愈合进程及相关临床发现。用SBCL治疗的10只猫中有8只(80%)角膜缺损完全愈合,角膜轻度瘢痕形成,且无眼部疼痛或不适的迹象。与G-CTF组和G-CO组相比,用SHBCL治疗的所有猫均未观察到肉芽组织。此外,未发现角膜干尸化或粘连的残留,SHBCL治疗组的角膜清晰度更高。总之,在切除相关干尸化组织后,将SHBCL应用于角膜缺损可促进角膜愈合,并在短时间内显著提高角膜清晰度和透明度。