Denk Nora, Fritsche Jens, Reese Sven
Department of Small Animal Surgery, Ludwig-Maximilians-Universität München (LMU), Veterinärstrasse 13, 80539 Munich, Germany.
Vet Ophthalmol. 2011 May;14(3):186-94. doi: 10.1111/j.1463-5224.2010.00863.x.
To evaluate the effect of UV-blocking soft contact lenses in treatment for chronic superficial keratitus (CSK).
Twenty six dogs with CSK were treated continuously with UV-blocking contact lenses for 6 months. A contact lens was placed on one eye of each dog; the other eye remained without a lens as a control eye. After this primary study, five of the dogs were further treated and they wore then contact lenses in both eyes. Continuously, all patients were concurrently treated topically with cyclosporine. The contact lenses were changed every 4 weeks and an ophthalmic examination performed. Evaluation criteria included corneal alterations as pigmentation, edema, pannus and vascularization. To determine the transmittance characteristics of the contact lenses before and after use, 32 contact lenses were measured with a UV-vis-NIR spectrophotometer.
Pigmentation increased in eyes wearing lenses and in control eyes over the evaluation period of 6 months. Corneal edema increased in the eyes wearing lenses, but remained unaffected in the control eyes. A significant difference in the incidence of pannus and the extent of corneal vascularisation could not be evaluated. Adverse effects were noted in six cases (corneal edema and vascularisation, conjunctivitis, blepharospasm). All new lenses studied reduced UV-radiation to a safe level, whereas used lenses did not maintain their transmittance characteristics.
No positive effect of UV-blocking contact lenses could be proven with the study design used.
评估防紫外线软性隐形眼镜治疗慢性浅层角膜炎(CSK)的效果。
26只患有CSK的犬连续佩戴防紫外线隐形眼镜6个月。每只犬的一只眼睛佩戴隐形眼镜;另一只眼睛不戴作为对照。在这项初步研究之后,其中5只犬进一步接受治疗,双眼都佩戴隐形眼镜。所有犬同时局部使用环孢素进行治疗。隐形眼镜每4周更换一次,并进行眼科检查。评估标准包括角膜变化,如色素沉着、水肿、血管翳和血管化。为了测定使用前后隐形眼镜的透光特性,用紫外-可见-近红外分光光度计对32片隐形眼镜进行了测量。
在6个月的评估期内,佩戴隐形眼镜的眼睛和对照眼睛的色素沉着均增加。佩戴隐形眼镜的眼睛角膜水肿增加,但对照眼睛未受影响。血管翳的发生率和角膜血管化程度的显著差异无法评估。有6例出现不良反应(角膜水肿和血管化、结膜炎、眼睑痉挛)。所有研究的新隐形眼镜都将紫外线辐射降低到了安全水平,而用过的隐形眼镜则不能保持其透光特性。
采用本研究设计未能证明防紫外线隐形眼镜有积极效果。