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1
Common individual antigenic determinants in five of eight BALB-c IgA myeloma proteins that bind phosphoryl choline.八种结合磷酸胆碱的BALB-c IgA骨髓瘤蛋白中的五种的常见个体抗原决定簇。
J Exp Med. 1970 Oct 1;132(4):737-51. doi: 10.1084/jem.132.4.737.
2
Three IgA myeloma immunoglobulins from the BALB/ mouse: precipitation with pneumococcal C polysaccharide.来自BALB/c小鼠的三种IgA骨髓瘤免疫球蛋白：与肺炎球菌C多糖的沉淀反应
Science. 1968 Oct 18;162(3851):369-71. doi: 10.1126/science.162.3851.369.
3
Structural, functional, and idiotypic characteristics of a phosphorylcholine-binding IgA myeloma protein of C57BL/ka allotype.C57BL/ka同种异型磷酸胆碱结合IgA骨髓瘤蛋白的结构、功能及独特型特征
J Exp Med. 1975 Mar 1;141(3):608-19. doi: 10.1084/jem.141.3.608.
4
Autoimmune-like antibodies to the ligand-binding sites of myeloma proteins.针对骨髓瘤蛋白配体结合位点的自身免疫样抗体。
Proc Natl Acad Sci U S A. 1971 Dec;68(12):3130-5. doi: 10.1073/pnas.68.12.3130.
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Myeloma proteins (M-components) with antibody-like activity.具有抗体样活性的骨髓瘤蛋白（M成分）。
N Engl J Med. 1971 Apr 15;284(15):831-8. doi: 10.1056/NEJM197104152841507.
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Specificity for phosphorylcholine of six murine myeloma proteins reactive with Pneumococcus C polysaccharide and beta-lipoprotein.
Biochemistry. 1971 Apr 13;10(8):1424-9. doi: 10.1021/bi00784a024.
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Experimental approaches to homogenous antibody populations. Mouse IgA myeloma proteins that bind polysaccharide antigens of enterobacterial origin.获得同源抗体群体的实验方法。结合肠道细菌来源多糖抗原的小鼠IgA骨髓瘤蛋白。
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[Individual antigenic specificity of mouse myeloma proteins].
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Myeloma proteins as tumor-specific transplantation antigens.骨髓瘤蛋白作为肿瘤特异性移植抗原。
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Broad specificity of monoclonal IgA (TEPC15-IgA) for enteric bacteria via phosphorylcholine-mediated interaction.通过磷酸胆碱介导的相互作用，单克隆 IgA（TEPC15-IgA）对肠道细菌具有广泛的特异性。
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IL-17 intensifies IFN-γ-induced NOS2 upregulation in RAW 264.7 cells by further activating STAT1 and NF-κB.白细胞介素-17通过进一步激活信号转导和转录激活因子1（STAT1）及核因子κB（NF-κB），增强干扰素-γ（IFN-γ）诱导的RAW 264.7细胞中一氧化氮合酶2（NOS2）的上调。
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The analysis of clonal expansions in normal and autoimmune B cell repertoires.正常和自身免疫性B细胞库中克隆扩增的分析。
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T-cell dependent response to immune complexes abrogates B-cell unresponsiveness to pneumococcal cell wall polysaccharide.对免疫复合物的T细胞依赖性反应消除了B细胞对肺炎球菌细胞壁多糖的无反应性。
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Anti-phosphocholine hybridoma antibodies. II. Functional analysis of binding sites within three antibody families.抗磷酸胆碱杂交瘤抗体。II. 三个抗体家族内结合位点的功能分析。
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Somatically generated mouse myeloma variants synthesizing IgA half-molecules.体细胞产生的合成 IgA 半分子的小鼠骨髓瘤变体。
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Generation of idiotype-specific T cell help through network perturbation.通过网络扰动产生独特型特异性T细胞辅助。
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本文引用的文献

1
Induction of plasma-cell neoplasms in strain BALB/c mice with mineral oil and mineral oil adjuvants.用矿物油和矿物油佐剂在BALB/c品系小鼠中诱导浆细胞瘤。
Nature. 1962 Mar 17;193:1086-7. doi: 10.1038/1931086a0.
2
INDIVIDUAL ANTIGENIC SPECIFICITY OF MYELOMA PROTEINS. CHARACTERISTICS AND LOCALIZATION TO SUBUNITS.骨髓瘤蛋白的个体抗原特异性。特性及亚基定位
J Exp Med. 1965 Apr 1;121(4):561-75. doi: 10.1084/jem.121.4.561.
3
Induction of plasma cell tumours in BALB-c mice with 2,6,10,14-tetramethylpentadecane (pristane).用2,6,10,14-四甲基十五烷（角鲨烷）在BALB-c小鼠中诱导浆细胞瘤
Nature. 1969 Jun 7;222(5197):994-5. doi: 10.1038/222994a0.
4
IgG myeloma cryoglobulin with antistreptolysin activity.具有抗链球菌溶血素活性的IgG型骨髓瘤冷球蛋白
Nature. 1968 Nov 16;220(5168):711-2. doi: 10.1038/220711a0.
5
Quantitative investigations of idiotypic antibodies. I. Analysis of precipitating antibody populations.独特型抗体的定量研究。I. 沉淀抗体群体的分析。
J Exp Med. 1969 Nov 1;130(5):1047-62. doi: 10.1084/jem.130.5.1047.
6
Experimental approaches to homogenous antibody populations. Mouse IgA myeloma proteins that bind polysaccharide antigens of enterobacterial origin.获得同源抗体群体的实验方法。结合肠道细菌来源多糖抗原的小鼠IgA骨髓瘤蛋白。
Fed Proc. 1970 Jan-Feb;29(1):85-91.
7
Experimental approaches tohomogenous antibody populations. iIndividual antigenic specificity, cross specificity and diversity of human antibodies.针对同源抗体群体的实验方法。i人类抗体的个体抗原特异性、交叉特异性和多样性。
Fed Proc. 1970 Jan-Feb;29(1):55-8.
8
Immunochemical reactions of lipids.脂质的免疫化学反应。
Prog Allergy. 1969;13:273-331.
9
Idiotypy of rabbit antibodies. I. Comparison of idiotypy of antibodies against Salmonella typhi with that of antibodies against other bacteria in the same rabbits, or of antibodies against Salmonella typhi in various rabbits.兔抗体的独特型。I. 同一兔体内抗伤寒沙门氏菌抗体与抗其他细菌抗体的独特型比较，或不同兔体内抗伤寒沙门氏菌抗体的独特型比较。
J Exp Med. 1969 Sep 1;130(3):595-617. doi: 10.1084/jem.130.3.595.
10
Pneumococcal C-substance, a ribitol teichoic acid containing choline phosphate.肺炎球菌C物质，一种含磷酸胆碱的核糖醇壁酸。
Biochem J. 1968 Dec;110(3):573-82. doi: 10.1042/bj1100573.

八种结合磷酸胆碱的BALB-c IgA骨髓瘤蛋白中的五种的常见个体抗原决定簇。

Common individual antigenic determinants in five of eight BALB-c IgA myeloma proteins that bind phosphoryl choline.

作者信息

Potter M, Lieberman R

出版信息

J Exp Med. 1970 Oct 1;132(4):737-51. doi: 10.1084/jem.132.4.737.

DOI:10.1084/jem.132.4.737
PMID:4101363
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2138855/
Abstract

Eight IgA myeloma proteins derived from independently induced plasma-cytomas in genetically similar inbred BALB/c mice are functionally related by their binding of phosphoryl choline-containing antigens (Pneumococcus C polysaccharide or Lactobacillus antigen). Each protein resembles a single species of immunoglobulin in antibody. The proteins are characterized by highly sensitive myeloma-specific antisera prepared by immunizing mice of other inbred strains with the BALB/c myeloma proteins. Individual or myeloma-specific determinants located on Fab fragments were found on three of the proteins that were unique for that protein and did not react with any other IgA protein among over 70 tested. Remarkably, five of the proteins shared two common myeloma-specific determinants which were specific for this group of five proteins. These results suggest that the five functionally and genetically related proteins sharing the same myeloma-specific determinants might also be structurally similar.

摘要

从基因相似的近交系BALB/c小鼠中独立诱导产生的浆细胞瘤衍生出的8种IgA骨髓瘤蛋白，通过它们与含磷酸胆碱抗原（肺炎球菌C多糖或乳酸杆菌抗原）的结合而在功能上相关。每种蛋白在抗体方面类似于单一物种的免疫球蛋白。这些蛋白的特征在于通过用BALB/c骨髓瘤蛋白免疫其他近交系小鼠制备的高度敏感的骨髓瘤特异性抗血清。在其中三种蛋白上发现了位于Fab片段上的个体或骨髓瘤特异性决定簇，这些决定簇是该蛋白所特有的，并且在超过70种测试的IgA蛋白中不与任何其他IgA蛋白发生反应。值得注意的是，其中五种蛋白共享两个共同的骨髓瘤特异性决定簇，这些决定簇是这一组五种蛋白所特有的。这些结果表明，共享相同骨髓瘤特异性决定簇的这五种功能和基因相关的蛋白在结构上可能也相似。