Potter M, Leon M A
Science. 1968 Oct 18;162(3851):369-71. doi: 10.1126/science.162.3851.369.
Three of 64 IgA immunoglobuilins, derived from plasma cell tumors induced by mineral oil in BALB/c mice, precipitated with species-specific pneumococcus C polysaccharide. A related antigen was also found in group O and some group H streptococci. A difference in ability to precipitate a C polysaccharide from a pneumococcus type XIV was demonstrated between protein 603 which did precipitate and protein 167 which did not precipitate this polysaccharide. Studies of the 167 and 603 proteins showed differences in electrophoretic mobility and polypeptide chains. The antigen-combining site of the 167 and 603 proteins resided on the papain-digestion Fab fragment.
在BALB/c小鼠中，由矿物油诱导产生的64种IgA免疫球蛋白中有3种能与种特异性肺炎球菌C多糖沉淀。在O群和一些H群链球菌中也发现了一种相关抗原。能沉淀肺炎球菌14型C多糖的603蛋白和不能沉淀该多糖的167蛋白之间，在沉淀能力上存在差异。对167和603蛋白的研究表明，它们在电泳迁移率和多肽链方面存在差异。167和603蛋白的抗原结合位点位于木瓜蛋白酶消化后的Fab片段上。
