Salonsalmi Aino, Lahti Jouni, Lahelma Eero, Rahkonen Ossi, Lallukka Tea
Department of Public Health, University of Helsinki, PO Box 20 (Tukholmankatu 8 B), 00014, Helsinki, Finland.
Finnish Institute for Health and Welfare, Helsinki, Finland.
Soc Psychiatry Psychiatr Epidemiol. 2025 Sep 27. doi: 10.1007/s00127-025-02996-z.
To examine the association between drinking patterns and subsequent antidepressant medication using register-linked data.
The Helsinki Health Study survey (2000-02) of 40- to 60-year-old employees was linked with antidepressant medication data from registers of the Social Insurance Institution of Finland. Drinking patterns included weekly amount of drinking, binge drinking and problem drinking. Cox regression analysis was used to calculate hazard ratios (HR) for the first antidepressant medication purchase during five-year follow-up. Gender, age, occupational position, marital status, relative weight, smoking and leisure-time physical activity were included as covariates. The study included 5727 employees with no antidepressant purchase during 3 years preceding the baseline.
Heavy drinking was associated with an increased risk of antidepressant medication compared to moderate drinking (HR 1.53, 95% CI 1.18-1.99). Non-drinkers (1.43, 1.03-1.97), occasional binge drinkers (1.27, 1.06-1.52) and frequent binge drinkers (1.35 (1.02-1.77) showed an association with antidepressant medication compared to non-bingeing drinkers. Problem drinking was associated with antidepressant medication (1.84, 1.54-2.19). The associations remained after adjusting for occupational position and for marital status. The associations concerning heavy drinking and problem drinking remained also after adjusting for relative weight and health behaviours. An additional analysis among participants with prior antidepressant medication before baseline, showed no associations between drinking patterns and subsequent antidepressant medication during the follow-up.
Alcohol drinking is associated with antidepressant medication among employees. The association is not limited to problem drinking. Paying attention to heavy, binge and problem drinking might help prevent depression.
利用登记关联数据研究饮酒模式与后续抗抑郁药物使用之间的关联。
对40至60岁员工进行的赫尔辛基健康研究调查（2000 - 2002年）与芬兰社会保险机构登记册中的抗抑郁药物数据相关联。饮酒模式包括每周饮酒量、暴饮和问题饮酒。采用Cox回归分析计算五年随访期间首次购买抗抑郁药物的风险比（HR）。将性别、年龄、职业地位、婚姻状况、相对体重、吸烟和休闲时间身体活动作为协变量纳入分析。该研究纳入了5727名在基线前3年未购买过抗抑郁药物的员工。
与适度饮酒相比，重度饮酒与抗抑郁药物使用风险增加相关（HR 1.53，95% CI 1.18 - 1.99）。与非暴饮者相比，不饮酒者（1.43，1.03 - 1.97）、偶尔暴饮者（1.27，1.06 - 1.52）和频繁暴饮者（1.35（1.02 - 1.77）与抗抑郁药物使用相关。问题饮酒与抗抑郁药物使用相关（1.84，1.54 - 2.19）。在调整职业地位和婚姻状况后，这些关联仍然存在。在调整相对体重和健康行为后，重度饮酒和问题饮酒的关联也仍然存在。对基线前曾使用过抗抑郁药物的参与者进行的额外分析显示，随访期间饮酒模式与后续抗抑郁药物使用之间无关联。
员工饮酒与抗抑郁药物使用相关。这种关联不仅限于问题饮酒。关注重度、暴饮和问题饮酒可能有助于预防抑郁症。
