Bao Phuong H, Friedland David R, Adams Jazzmyne A, Freed Julie K, Khani Masoud, Luo Jake
Department of Otolaryngology and Communication Sciences, Medical College of Wisconsin, Milwaukee, Wisconsin.
Caruso Department of Otolaryngology-Head and Neck Surgery, University of Southern California, Los Angeles, CA.
Otol Neurotol Open. 2025 Jul 14;5(3):e075. doi: 10.1097/ONO.0000000000000075. eCollection 2025 Sep.
Otologic surgery has specific anesthetic requirements such as avoiding nitrous oxide and allowing facial nerve monitoring, but lacks clear criteria for an optimal anesthetic regimen, often relying on anesthesiologist preference.
This study is a retrospective review of 600 primary cochlear implant surgeries and anesthetic variables.
This study was conducted in a tertiary academic medical center.
Univariate, multivariate, and cluster analyses of anesthetic regimen association with clinical metrics of postoperative recovery.
Among 600 cochlear implant surgeries, anesthesia regimens included balanced (combination of gas and intravenous agents) (84.3%), gas alone (13.5%), and total intravenous anesthesia (TIVA) (2.2%). By univariate analysis, emergence from anesthesia was shortest with TIVA (11.9 ± 4.6 minutes) and longest with gas (14.2 ± 5.3 minutes), although not reaching statistical significance. Univariate analyses also failed to show a significant correlation between anesthesia regimen and phase I recovery or phase II duration. Multivariate regression indicated significantly shorter emergence times with TIVA compared with gas alone (coeff: -5.29, = 0.0027). Cluster analysis identified 3 groups based on relative remifentanil and gas usage. Patients in cluster 1 (low gas and high remifentanil) had significantly longer emergence times than those in clusters 2 (low gas, low remifentanil: 16.26 ± 5.96 vs 13.39 ± 5.30 minutes; = 0.001) and 3 (high gas, low remifentanil: 16.26 ± 5.96 vs 13.47 ± 5.48 minutes; = 0.0069). Cluster 1 also had longer phase 1 recovery times compared with clusters 2 (65.33 ± 28.87 vs 54.33 ± 25.36 minutes; = 0.0085) and 3 (65.33 ± 28.87 vs 56.38 ± 20.81 minutes; = 0.0365).
TIVA anesthetic regimen is associated with shorter emergence time than gas alone, although the difference in time is small. Balanced regimens are most used among anesthesiologists, and limiting remifentanil dosage may shorten emergence and recovery times.
耳科手术有特定的麻醉要求,如避免使用氧化亚氮并允许进行面神经监测,但缺乏关于最佳麻醉方案的明确标准,通常依赖麻醉医生的偏好。
本研究是对600例原发性人工耳蜗植入手术及麻醉变量的回顾性分析。
本研究在一家三级学术医疗中心进行。
对麻醉方案与术后恢复临床指标进行单因素、多因素和聚类分析。
在600例人工耳蜗植入手术中,麻醉方案包括平衡麻醉(气体和静脉药物联合使用)(84.3%)、单纯气体麻醉(13.5%)和全静脉麻醉(TIVA)(2.2%)。单因素分析显示,TIVA麻醉后苏醒时间最短(11.9±4.6分钟),单纯气体麻醉最长(14.2±5.3分钟),但未达到统计学显著性。单因素分析也未显示麻醉方案与I期恢复或II期持续时间之间存在显著相关性。多因素回归表明,与单纯气体麻醉相比,TIVA麻醉后的苏醒时间显著缩短(系数:-5.29,P = 0.0027)。聚类分析根据瑞芬太尼和气体的相对使用量确定了3组。第1组(低气体、高瑞芬太尼)患者的苏醒时间显著长于第2组(低气体、低瑞芬太尼:16.26±5.96对13.39±5.30分钟;P = 0.001)和第3组(高气体、低瑞芬太尼:16.26±5.96对13.47±5.48分钟;P = 0.0069)。与第2组(65.33±28.87对54.33±25.36分钟;P = 0.0085)和第3组(65.33±28.87对56.38±20.81分钟;P = 0.0365)相比,第1组的I期恢复时间也更长。
TIVA麻醉方案与比单纯气体麻醉更短的苏醒时间相关,尽管时间差异较小。平衡麻醉方案在麻醉医生中使用最为广泛,限制瑞芬太尼剂量可能会缩短苏醒和恢复时间。