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研究SARM1在中枢神经系统中的作用。

Investigating the role of SARM1 in central nervous system.

作者信息

Wang Junjie, Shi Yuhang, Tian Jinglei, Tang Liming, Cao Fang

机构信息

Department of Neurosurgery Affiliated Hospital of Zunyi Medical University Zunyi China.

出版信息

Ibrain. 2024 Aug 14;11(3):297-305. doi: 10.1002/ibra.12173. eCollection 2025 Fall.

DOI:10.1002/ibra.12173
PMID:41018229
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12465223/
Abstract

Sterile-α and Toll/interleukin 1 receptor (TIR) motif-containing protein 1 (SARM1), a key intracellular molecule that plays numerous important biological functions in the nervous system, has attracted much attention. Recent studies have shown that SARM1 plays a key role in nerve injury, degeneration, and neurodegenerative diseases. Therefore, understanding the role of SARM1 in the central nervous system (CNS) will enhance our knowledge of the pathogenesis of CNS diseases and aid in the development of new therapeutic strategies. This review will explore the biological functions of SARM1 in the nervous system and its potential roles in nerve injury and disease, thus providing new directions for future research and treatment.

摘要

含无菌α和Toll/白细胞介素1受体（TIR）基序蛋白1（SARM1）是一种在神经系统中发挥多种重要生物学功能的关键细胞内分子，已引起广泛关注。最近的研究表明，SARM1在神经损伤、变性和神经退行性疾病中起关键作用。因此，了解SARM1在中枢神经系统（CNS）中的作用将增进我们对CNS疾病发病机制的认识，并有助于开发新的治疗策略。本综述将探讨SARM1在神经系统中的生物学功能及其在神经损伤和疾病中的潜在作用，从而为未来的研究和治疗提供新方向。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b89/12465223/84fb69507a27/IBRA-11-297-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b89/12465223/6afd4fe696a1/IBRA-11-297-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b89/12465223/1409602c642a/IBRA-11-297-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b89/12465223/fdcc7efc3cb8/IBRA-11-297-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b89/12465223/84fb69507a27/IBRA-11-297-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b89/12465223/6afd4fe696a1/IBRA-11-297-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b89/12465223/1409602c642a/IBRA-11-297-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b89/12465223/fdcc7efc3cb8/IBRA-11-297-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b89/12465223/84fb69507a27/IBRA-11-297-g001.jpg

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1
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Ibrain. 2024 Aug 14;11(3):297-305. doi: 10.1002/ibra.12173. eCollection 2025 Fall.
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本文引用的文献

1
Syntaphilin Inactivation Can Enhance Axonal Mitochondrial Transport to Improve Spinal Cord Injury.突触融合蛋白失活可增强轴突线粒体运输，改善脊髓损伤。
Mol Neurobiol. 2023 Nov;60(11):6556-6565. doi: 10.1007/s12035-023-03494-6. Epub 2023 Jul 17.
2
Loss of the extracellular matrix protein Perlecan disrupts axonal and synaptic stability during development.细胞外基质蛋白 Perlecan 的缺失会破坏发育过程中的轴突和突触稳定性。
Elife. 2023 Jun 27;12:RP88273. doi: 10.7554/eLife.88273.
3
SARM1 Promotes Neurodegeneration and Memory Impairment in Mouse Models of Alzheimer's Disease.
SARM1 促进阿尔茨海默病小鼠模型中的神经退行性变和记忆损伤。
Aging Dis. 2024 Feb 1;15(1):390-407. doi: 10.14336/AD.2023.0516-1.
4
SARM1 promotes the neuroinflammation and demyelination through IGFBP2/NF-κB pathway in experimental autoimmune encephalomyelitis mice.SARM1 通过 IGFBP2/NF-κB 通路促进实验性自身免疫性脑脊髓炎小鼠的神经炎症和脱髓鞘。
Acta Physiol (Oxf). 2023 Jun;238(2):e13974. doi: 10.1111/apha.13974. Epub 2023 Apr 25.
5
SARM1 detection in myelinating glia: / is dispensable for PNS and CNS myelination in zebrafish and mice.在有髓神经胶质细胞中检测SARM1：/对斑马鱼和小鼠的周围神经系统和中枢神经系统髓鞘形成并非必需。
Front Cell Neurosci. 2023 Apr 5;17:1158388. doi: 10.3389/fncel.2023.1158388. eCollection 2023.
6
Prioritization of Drug Targets for Neurodegenerative Diseases by Integrating Genetic and Proteomic Data From Brain and Blood.通过整合来自大脑和血液的遗传和蛋白质组学数据对神经退行性疾病的药物靶点进行优先级排序
Biol Psychiatry. 2023 May 1;93(9):770-779. doi: 10.1016/j.biopsych.2022.11.002. Epub 2022 Nov 9.
7
Autophagy protein ULK1 interacts with and regulates SARM1 during axonal injury.自噬蛋白 ULK1 在轴突损伤过程中与 SARM1 相互作用并调节其活性。
Proc Natl Acad Sci U S A. 2022 Nov 22;119(47):e2203824119. doi: 10.1073/pnas.2203824119. Epub 2022 Nov 14.
8
Preparation of DSPE-PEG-cRGD Modified Cationic Liposomes for Delivery of OC-2 shRNA and The Antitumor Effects on Breast Cancer.用于递送OC-2 shRNA的DSPE-PEG-cRGD修饰阳离子脂质体的制备及其对乳腺癌的抗肿瘤作用
Pharmaceutics. 2022 Oct 10;14(10):2157. doi: 10.3390/pharmaceutics14102157.
9
Traumatic axonopathy in spinal tracts after impact acceleration head injury: Ultrastructural observations and evidence of SARM1-dependent axonal degeneration.撞击性加速头部损伤后脊髓束中的创伤性轴索病：超微结构观察及 SARM1 依赖性轴索变性的证据。
Exp Neurol. 2023 Jan;359:114252. doi: 10.1016/j.expneurol.2022.114252. Epub 2022 Oct 13.
10
Early loss of endogenous NAD following rotenone treatment leads to mitochondrial dysfunction and Sarm1 induction that is ameliorated by PARP inhibition.鱼藤酮处理后内源性烟酰胺腺嘌呤二核苷酸（NAD）的早期丧失导致线粒体功能障碍和含 sterile α 和 armadillo 基序蛋白1（Sarm1）的诱导，而这种诱导可通过聚（ADP-核糖）聚合酶（PARP）抑制得到改善。
FEBS J. 2023 Mar;290(6):1596-1624. doi: 10.1111/febs.16652. Epub 2022 Oct 24.