Department of Histology and Embryology, Medical College, Shaoxing University, Shaoxing, 312000, Zhejiang, China.
Institute of Neuroscience, Zhejiang University School of Medicine, Hangzhou, China.
Mol Neurobiol. 2023 Nov;60(11):6556-6565. doi: 10.1007/s12035-023-03494-6. Epub 2023 Jul 17.
Mitochondria are important organelle of eukaryotic cells. They consists of a large number of different proteins that provide most of the ATP and supply power for the growth, function, and regeneration of neurons. Therefore, smitochondrial transport ensures that adequate ATP is supplied for metabolic activities. Spinal cord injury (SCI), a detrimental condition, has high morbidity and mortality rates. Currently, the available treatments only provide symptomatic relief for long-term disabilities. Studies have implicated mitochondrial transport as a critical factor in axonal regeneration. Hence, enhancing mitochondrial transports could be beneficial for ameliorating SCI. Syntaphilin (Snph) is a mitochondrial docking protein that acts as a "static anchor," and its inhibition enhances mitochondrial transports. Therefore, Snph as a key mediator of mitochondrial transports, may contribute to improving axonal regeneration following SCI. Herein, we examine Snph's biological effects and its relation to mitochondrial pathway. Then, we elaborate on mitochondrial transports after SCI, the possible role of Snph in SCI, and some possible therapeutic approaches by Snph.
线粒体是真核细胞的重要细胞器。它们由大量不同的蛋白质组成，为神经元的生长、功能和再生提供大部分的 ATP 并提供动力。因此，线粒体的运输确保了足够的 ATP 供应来进行代谢活动。脊髓损伤 (SCI) 是一种有害的疾病，其发病率和死亡率都很高。目前，现有的治疗方法仅能为长期残疾提供对症缓解。研究表明，线粒体运输是轴突再生的关键因素。因此，增强线粒体的运输可能有助于改善 SCI。Syntaphilin (Snph) 是一种线粒体对接蛋白，它作为一种“静态锚”，其抑制作用增强了线粒体的运输。因此，Snph 作为线粒体运输的关键介质，可能有助于改善 SCI 后的轴突再生。本文中，我们研究了 Snph 的生物学作用及其与线粒体途径的关系。然后，我们详细阐述了 SCI 后线粒体的运输、Snph 在 SCI 中的可能作用，以及 Snph 的一些可能的治疗方法。
