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用于核医学的铂族金属，是奢侈的梦想还是成像与治疗的未来：综述

Platinum group metals for nuclear medicine, a luxurious dream or the future of imaging and therapy: a review.

作者信息

Racz Daniel G, Chaple Ivis F

机构信息

Department of Nuclear Engineering, University of Tennessee, Knoxville, TN, United States.

出版信息

Front Nucl Med. 2025 Sep 11;5:1656374. doi: 10.3389/fnume.2025.1656374. eCollection 2025.

DOI:10.3389/fnume.2025.1656374
PMID:41018941
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12460398/
Abstract

Platinum group metals (PGMs) consist of six transition metals: platinum (Pt), palladium (Pd), rhodium (Rh), osmium (Os), iridium (Ir), and ruthenium (Ru). PGMs have been used notably in industrial, electronic, and medical applications. For example, Ir-192 is often utilized in industry to detect structural defects in metal and assess pipeline integrity. Pd-104 is irradiated to produce Pd-103 seeds, used for prostate cancer treatment. Other isotopes of elements in this group can be sourced to facilitate critical applications, discussed in this review. Due to their unique chemical and nuclear properties, these metals may be promising candidates for various nuclear medicine applications, including diagnostic imaging via Positron Emission Tomography (PET), Single Photon Emission Computed Tomography (SPECT) and Targeted Radionuclide Therapy (TRT). This review will explore PGMs in nuclear medicine, focusing on their production routes, nuclear characteristics, and suitability for past and future development of radiopharmaceuticals. We will highlight methods for radiochemical separation and purification of each radionuclide, discussing potential challenges and emphasizing the need for further research to ensure sustainability. As the demand for advanced nuclear medicine techniques continues to grow, PGMs may play a significant role in addressing current challenges in the field. We will discuss several radionuclides of interest to nuclear medicine including Pt, Pt, Pt, Pd, Pd, Rh, Rh, Os, Ir, Ru, and Ru.

摘要

铂族金属（PGMs）由六种过渡金属组成：铂（Pt）、钯（Pd）、铑（Rh）、锇（Os）、铱（Ir）和钌（Ru）。铂族金属已在工业、电子和医疗应用中得到显著应用。例如，铱 - 192常用于工业中检测金属结构缺陷和评估管道完整性。钯 - 104经辐照可产生用于前列腺癌治疗的钯 - 103种子源。该族元素的其他同位素可用于促进关键应用，本综述将对此进行讨论。由于其独特的化学和核性质，这些金属可能是各种核医学应用的有前景的候选者，包括通过正电子发射断层扫描（PET）、单光子发射计算机断层扫描（SPECT）和靶向放射性核素治疗（TRT）进行诊断成像。本综述将探讨核医学中的铂族金属，重点关注其生产路线、核特性以及对放射性药物过去和未来发展的适用性。我们将突出每种放射性核素的放射化学分离和纯化方法，讨论潜在挑战并强调进一步研究以确保可持续性的必要性。随着对先进核医学技术的需求持续增长，铂族金属可能在应对该领域当前挑战中发挥重要作用。我们将讨论核医学感兴趣的几种放射性核素，包括铂（Pt）、铂（Pt）、铂（Pt）、钯（Pd）、钯（Pd）、铑（Rh）、铑（Rh）、锇（Os）、铱（Ir）、钌（Ru）和钌（Ru）。

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2
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3
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Optimized chelator and nanoparticle strategies for high-activity Pd-loaded biodegradable brachytherapy seeds.用于高活性载钯可生物降解近距离放射治疗种子的优化螯合剂和纳米颗粒策略。
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8
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