Poznyak Anastasia V, Kozlov Sergey, Babayeva Gulalek A, Sukhorukov Vasily N, Orekhov Alexander N
Institute for Atherosclerosis Research, Moscow, Russia.
Chazov National Medical Research Center of Cardiology of the Ministry of Health of the Russian Federation, Moscow, Russia.
Clin Med Insights Cardiol. 2025 Sep 24;19:11795468241291640. doi: 10.1177/11795468241291640. eCollection 2025.
Atherosclerosis is chronic arterial wall damage, which often results in cardiovascular disease development. Since atherosclerosis is almost asymptomatic, it is difficult to detect this condition, but it is even more difficult to deal with the consequences. The reasons for the development of atherosclerosis are still not completely clear, but the mechanisms involved in atherogenesis are known. Among them, lipid metabolism alterations, oxidative stress, as well as impaired mitochondrial function take pride of place. In our review, we want to dwell in more detail on such a component as lipid metabolism disorders. In particular, triglycerides, their levels, and influence on the development of the disease. Triglycerides provide the second-largest source of energy. In the context of atherosclerosis, the question arises, is an increase in the level of triglycerides in the blood a cause, a biomarker, or a consequence of the processes accompanying atherogenesis?
动脉粥样硬化是一种慢性动脉壁损伤，常导致心血管疾病的发生。由于动脉粥样硬化几乎没有症状，很难检测到这种情况，但其后果更难处理。动脉粥样硬化的发病原因尚不完全清楚，但动脉粥样硬化形成的机制是已知的。其中，脂质代谢改变、氧化应激以及线粒体功能受损最为突出。在我们的综述中，我们想更详细地探讨脂质代谢紊乱这一组成部分。特别是甘油三酯、它们的水平以及对疾病发展的影响。甘油三酯是第二大能量来源。在动脉粥样硬化的背景下，就会产生一个问题，即血液中甘油三酯水平的升高是动脉粥样硬化发生过程的原因、生物标志物还是结果？
