Moser Nina, Borbély Yves
Department of Visceral Surgery and Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
iScience. 2025 Sep 1;28(10):113468. doi: 10.1016/j.isci.2025.113468. eCollection 2025 Oct 17.
We summarize the current literature on acoustic voice analysis in gastroesophageal (GERD) and laryngopharyngeal (LPRD) reflux disease. Literature search on Pubmed and Cochrane Library between 04/-18/12/2023; all study types, keywords "reflux"/"voice"/"analysis", publication dates between 01/01/2000 and 18/12/2023, only publications dealing with acoustic voice analysis in reflux patients. = 33 clinical trials found and analyzed. = 27/33 publications confirm reproducible changes in acoustic voice analyses of reflux patients. Most studies worked with recording of vowel /a/ and used the software Kay Elemetrics MDVP. Most frequently analyzed parameters were fundamental frequency, percent/jitter, percent/shimmer. Results were quite inhomogeneous, not least due to the inconsistent study settings (analysis techniques and software), as well as mainly small, monocentric study designs. But acoustic voice analysis has potential; apart from LPRD patients, general GERD patients have hardly been analyzed and new possibilities are expected with technical advances.
我们总结了目前关于胃食管反流病（GERD）和喉咽反流病（LPRD）中声学嗓音分析的文献。于2023年12月18日在PubMed和Cochrane图书馆进行文献检索；涵盖所有研究类型，关键词为“反流”/“嗓音”/“分析”，发表日期在2000年1月1日至2023年12月18日之间，仅纳入涉及反流患者声学嗓音分析的出版物。共找到并分析了33项临床试验。33篇出版物中有27篇证实了反流患者声学嗓音分析中存在可重复的变化。大多数研究采用元音/a/的录音，并使用Kay Elemetrics MDVP软件。最常分析的参数是基频、抖动百分比、闪烁百分比。结果相当不一致，这主要是由于研究设置（分析技术和软件）不一致，以及主要是小型的单中心研究设计。但声学嗓音分析具有潜力；除了LPRD患者外，一般GERD患者几乎未被分析，随着技术进步有望出现新的可能性。
