Rapid drug detection equipment based on molecular imprinting and surface plasmon resonance technology.

This study develops high-sensitivity drug detection equipment combining molecular imprinting technology (MIT) and surface plasmon resonance (SPR) for rapid methamphetamine hydrochloride (MAPA) analysis. The MIT-SPR sensor chip exhibits a detection limit of 2.97×10 g/mL (0.003 ng/mL), maintains 98.5% sensitivity after 50 days, and achieves 97.3-101.7% recovery in dust samples. The chip demonstrates excellent reusability (8 adsorption-elution cycles) and specificity, with minimal cross-reactivity to structural analogs. Three field-deployable devices were designed for wastewater monitoring, multi-channel sampling, and portable dust detection, enabling real-time data transmission to law enforcement. Compared to traditional methods (e.g., GC, HPLC), this system offers superior sensitivity, faster response (6-10 min), and minimal sample pretreatment. The technology supports diverse sample types (sewage, organic liquids, dust) and reduces false alarms, enhancing anti-drug operations.