Meer Anzila, Sulong Sarina, Mat Zin Anani Aila, Mohamud Rohimah, Mat Lazim Norhafiza
Universiti Sains Malaysia, School of Medical Sciences, Department of Otorhinolaryngology-Head and Neck Surgery, Health Campus, Kelantan, Malaysia.
Universiti Sains Malaysia, School of Medical Sciences, Human Genome Centre, Health Campus, Kelantan, Malaysia.
Medeni Med J. 2025 Sep 29;40(3):187-192. doi: 10.4274/MMJ.galenos.2025.63838.
Salivary gland tumors (SGTs) pose considerable diagnostic and treatment challenges due to their heterogeneous nature, diverse histogenesis, and unpredictable clinical outcomes. Benign tumors exhibit a known recurrence rate, whereas malignant tumors are associated with a poor prognosis and a low recovery rate. Nonetheless, despite the growing body of research, there is insufficient evidence to establish a link between SGTs, human papilloma virus (HPV) infection, and the hypermethylation of tumor suppressor genes. The aim of this study is to elucidate the relationship between DNA hypermethylation and HPV in SGTs, elucidate the role of DNA hypermethylation in HPV-associated SGTs, thereby offering insights into novel diagnostic, and prognostic markers. As epigenetic alterations significantly contribute to the development of carcinogenesis, addressing these epigenetic alterations may help in early treatment plans and early detection of SGTs.
唾液腺肿瘤（SGTs）因其异质性、多样的组织发生及不可预测的临床结局而带来了相当大的诊断和治疗挑战。良性肿瘤有已知的复发率，而恶性肿瘤则预后不良且康复率低。然而，尽管研究不断增多，但仍缺乏足够证据来确立SGTs、人乳头瘤病毒（HPV）感染与肿瘤抑制基因高甲基化之间的联系。本研究的目的是阐明SGTs中DNA高甲基化与HPV之间的关系，阐明DNA高甲基化在HPV相关SGTs中的作用，从而为新型诊断和预后标志物提供见解。由于表观遗传改变对致癌作用的发展有显著贡献，解决这些表观遗传改变可能有助于SGTs的早期治疗计划制定和早期检测。
