Abdu Nuru, Tewelde Tomas, Jabir Nerjis, Idrisnur Saleh, Tesfamariam Eyasu H
Medicine Information Services Unit, Pharmacy Services Division, Department of Medical Services, Ministry of Health, Asmara, Eritrea.
Gash-Barka Zonal Pharmaceutical Services, Ministry of Health, Barentu, Eritrea.
Sci Rep. 2025 Sep 29;15(1):33403. doi: 10.1038/s41598-025-18739-8.
Inappropriate prescribing of medicines could result in adverse drug reactions and interactions thereby leading to morbidity and mortality. Potential drug-drug interactions are preventable drug-related problems with the risks of hospitalization, adverse effects, and treatment failure. This study aimed to assess medication utilization patterns, and potential drug-drug interactions and its determinants among outpatient prescriptions. A cross-sectional survey was conducted. The study included dispensed outpatient prescriptions in six community chain pharmacies in Asmara, Eritrea, between June 16 and July 16, 2023. A stratified random sampling was utilized and drug interactions were screened using Lexi-comp drug interaction checker. Logistic regression was used to assess the determinants of clinically significant potential drug-drug interactions using IBM SPSS (version-26.0). A total of 417 outpatient prescriptions were included in the study. Moreover, a total of 830 medicines were prescribed from the 417 dispensed outpatient prescriptions. The most commonly prescribed medicines were omeprazole (8.4%) and amoxicillin (8.1%). Out of 267 prescriptions containing two or more medicines, the prevalence of clinically significant pDDIs was 29.2% (95%CI: 23.7, 34.7). The most common medicines involved in clinically significant pDDIs were diclofenac (22.6%) and ciprofloxacin (10.9%). Adult population (AOR = 4.23, 95%CI: 1.49, 12.01), older adult population (AOR = 7.09, 95%CI: 2.24, 22.44), number of drugs prescribed (AOR = 2.27, 95%CI: 1.53, 3.37), and tertiary level health facility (AOR = 9.13, 95%CI: 1.17, 71.42) were significant determinants of clinically significant pDDIs. Clinically significant pDDIs were detected in considerable number of outpatient prescriptions requiring strict monitoring from healthcare professionals, policy makers, and program managers.
不适当的药物处方可能导致药物不良反应和相互作用，从而导致发病和死亡。潜在的药物相互作用是可预防的与药物相关的问题，存在住院、不良反应和治疗失败的风险。本研究旨在评估门诊处方中的用药模式、潜在的药物相互作用及其决定因素。进行了一项横断面调查。该研究纳入了2023年6月16日至7月16日期间厄立特里亚阿斯马拉六家社区连锁药店发放的门诊处方。采用分层随机抽样，并使用Lexi-comp药物相互作用检查器筛查药物相互作用。使用IBM SPSS（版本26.0）进行逻辑回归分析，以评估具有临床意义的潜在药物相互作用的决定因素。该研究共纳入417份门诊处方。此外，从417份发放的门诊处方中共开出了830种药物。最常开具的药物是奥美拉唑（8.4%）和阿莫西林（8.1%）。在267份含有两种或更多药物的处方中，具有临床意义的药物相互作用的患病率为29.2%（95%置信区间：23.7，34.7）。参与具有临床意义的药物相互作用的最常见药物是双氯芬酸（22.6%）和环丙沙星（10.9%）。成年人群（比值比=4.23，95%置信区间：1.49，12.01）、老年人群（比值比=7.09，95%置信区间：2.24，22.44）、开具的药物数量（比值比=2.27，95%置信区间：1.53，3.37）和三级医疗机构（比值比=9.13，95%置信区间：1.17，71.42）是具有临床意义的药物相互作用的重要决定因素。在相当数量的门诊处方中检测到具有临床意义的药物相互作用，需要医疗专业人员、政策制定者和项目管理人员进行严格监测。
