Dirin Mandana Moradi, Mousavi Sarah, Afshari Amir Reza, Tabrizian Kaveh, Ashrafi Mohammad Hossein
Department of Clinical Pharmacy, Zabol University of Medical Sciences, Zabol, Iran.
Department of Clinical Pharmacy and Pharmacy Practice, Isfahan University of Medical Sciences, Isfahan, Iran.
J Res Pharm Pract. 2014 Jul;3(3):104-7. doi: 10.4103/2279-042X.141118.
This study aim to evaluate and compare type and prevalence of drug-drug interactions (DDIs) in prescriptions dispensed in both community and hospital setting in Zabol, Iran.
A total of 2796 prescriptions were collected from community and inpatient and outpatient pharmacy of Amir-al-momenin only current acting hospital in Zabol, Iran. The prescriptions were processed using Lexi-Comp drug interaction software. The identified DDIs were categorized into five classes (A, B, C, D, X).
Overall 41.6% of prescriptions had at last one potential DDI. The most common type of interactions was type C (66%). The percentage of drug interactions in community pharmacies were significantly lower than hospital pharmacies (P < 0.0001).
Our results indicate that patients in Zabol are at high risk of adverse drug reactions caused by medications due to potential DDIs. Appropriate education for physicians about potentially harmful DDIs, as well as active participation of pharmacists in detection and prevention of drug-related injuries, could considerably prevent the consequence of DDIs among patients.
本研究旨在评估和比较伊朗扎博勒社区和医院所开具处方中药物相互作用（DDIs）的类型及发生率。
从伊朗扎博勒仅有的一家现役医院——阿米尔 - 穆民医院的社区药房、住院药房和门诊药房共收集了2796份处方。使用Lexi - Comp药物相互作用软件对这些处方进行处理。识别出的药物相互作用被分为五类（A、B、C、D、X）。
总体而言，41.6%的处方至少有一种潜在的药物相互作用。最常见的相互作用类型为C类（66%）。社区药房的药物相互作用百分比显著低于医院药房（P < 0.0001）。
我们的结果表明，由于潜在的药物相互作用，扎博勒的患者面临因药物导致不良反应的高风险。对医生进行有关潜在有害药物相互作用的适当教育，以及药剂师积极参与药物相关损伤的检测和预防，可显著预防患者中药物相互作用的后果。
