Thakar J H, Percy D H, Strickland K P
Invest Ophthalmol Vis Sci. 1977 Nov;16(11):1047-52.
Eyes from cardiomyopathic hamsters (UM-X7.1 strain) were examined histologically for evidence of ocular defects. Changes observed included microphthalmia, scleral ectasia, scleral rupture, keratoconus, retinal detachment, retinal dysplasia, retinal fragmentation, retinal thinning, fibrosis of iris and ciliary body, ectopia lentis, and cataract formation. Lesions characteristic of cardiomyopathic hamsters were observed in the myocardium and skeletal muscle. This strain may be a suitable animal model to study the pathogenesis of ocular changes seen in certain congenital connective tissue disorders in man.
对来自心肌病仓鼠（UM-X7.1品系）的眼睛进行了组织学检查，以寻找眼部缺陷的证据。观察到的变化包括小眼症、巩膜扩张、巩膜破裂、圆锥角膜、视网膜脱离、视网膜发育异常、视网膜碎裂、视网膜变薄、虹膜和睫状体纤维化、晶状体异位和白内障形成。在心肌和骨骼肌中观察到了心肌病仓鼠特有的病变。该品系可能是研究人类某些先天性结缔组织疾病中所见眼部变化发病机制的合适动物模型。
