二苯胺诱导大肠杆菌的补体敏感性及抗原结构的相关变化。
Diphenylamine induced complement sensitivity and associated changes in the antigenic structure of Escherichia coli.
作者信息
Howard C J, Glynn A A
出版信息
Immunology. 1971 Dec;21(6):951-5.
Abstract
Growth in the presence of diphenylamine caused complement resistant strains of to become complement sensitive. Associated with this increased sensitivity was a fall in the amounts of specific O and K antigens extracted from the bacteria. Synthesis of the basal core of the O antigens was also affected. Nevertheless, there was an increased uptake of O antibody. Possible mechanisms by which complement sensitivity could be induced by diphenylamine are removal of the inhibitory effects of K antigen, and exposure of hidden antigenic determinants in the O antigen.
摘要
在二苯胺存在的情况下生长会使肺炎球菌的补体抗性菌株变得对补体敏感。与这种敏感性增加相关的是从细菌中提取的特异性O抗原和K抗原量的下降。O抗原基础核心的合成也受到影响。然而，O抗体的摄取增加。二苯胺诱导补体敏感性的可能机制是消除K抗原的抑制作用以及暴露O抗原中隐藏的抗原决定簇。
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