培养的鸡胚肝细胞中δ-氨基乙酰丙酸合成酶的诱导作用
Induction of -aminolevulinic acid synthetase in chick embryo liver cells in cluture.
作者信息
Sassa S, Granick S
出版信息
Proc Natl Acad Sci U S A. 1970 Oct;67(2):517-22. doi: 10.1073/pnas.67.2.517.
Abstract
delta-Aminolevulinic acid synthetase is induced in chick embryo liver culture by the natural steroid, etiocholanolone, and by the foreign chemical, 3,5-dicarbethoxy-1,4-dihydrocollidine at the level of transcription. Alternatively, inducing chemicals such as allylisopropylacetamide and gamma-hexachloro-cyclohexane act primarily at the level of translation. Hemin (K(i) = 5 muM) inhibits the induction at the level of translation. In liver cell culture, the half-life of delta-aminolevulinic acid synthetase is 3 hr, that of mRNA about 5 hr.
摘要
δ-氨基乙酰丙酸合成酶在鸡胚肝培养物中，可被天然类固醇化合物表雄酮以及外来化学物质3,5-二乙氧羰基-1,4-二氢可力丁在转录水平上诱导产生。另外，诸如烯丙基异丙基乙酰胺和γ-六六六等诱导性化学物质主要在翻译水平起作用。血红素（抑制常数Ki = 5 μM）在翻译水平抑制这种诱导作用。在肝细胞培养中，δ-氨基乙酰丙酸合成酶的半衰期为3小时，信使核糖核酸的半衰期约为5小时。
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