氨基青霉素在治疗耐氨苄西林的尿路感染中是否有作用？
Do Aminopenicillins Have a Role in Treating Ampicillin-Resistant UTIs?
作者信息
Hawes Armani M, Tamma Pranita D, Narayanan Navaneeth
机构信息
Division of Infectious Diseases, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
出版信息
Open Forum Infect Dis. 2025 Oct 8;12(10):ofaf619. doi: 10.1093/ofid/ofaf619. eCollection 2025 Oct.
Urinary tract infections caused by species are a frequent clinical challenge. The rising prevalence of ampicillin resistance often seemingly precludes the use of aminopenicillins. However, evidence suggests that aminopenicillins may retain clinical efficacy, even when susceptibility testing indicates resistance. Integrating available pharmacokinetics/pharmacodynamics and clinical data and risk-benefit considerations, we seek to address the question: Can aminopenicillins still be a viable treatment option in the management of ampicillin-resistant infections?
由该菌种引起的尿路感染是常见的临床挑战。氨苄西林耐药性的日益普遍似乎常常使氨基青霉素无法使用。然而，有证据表明，即使药敏试验显示耐药，氨基青霉素仍可能保留临床疗效。综合现有的药代动力学/药效学、临床数据及风险效益考量，我们试图解决以下问题：在治疗耐氨苄西林感染时，氨基青霉素是否仍可作为一种可行的治疗选择？
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