Cooper S M, Franklin E C, Frangione B
Science. 1972 Apr 14;176(4031):187-9. doi: 10.1126/science.176.4031.187.
The first gamma-2 (gamma2) heavy chain disease protein Gif has pyrroli-dinecarboxylic acid as its amino terminal residue, much of the Fd variable region, and an internal deletion of the heavy chain of about 100 residues corresponding to most of the Fd constant region. Normal sequence resumes with a glutamic acid residue at position 216 in the hinge region. This is the third gamma heavy chain disease protein where normal sequence resumes at the same position after the deletion.
首例γ-2（γ2）重链病蛋白Gif的氨基末端残基为脯氨酸羧酸，具有大部分Fd可变区，且重链有一段约100个残基的内部缺失，对应于大部分Fd恒定区。正常序列在铰链区第216位的谷氨酸残基处恢复。这是第三种γ重链病蛋白，缺失后在相同位置恢复正常序列。
