Franklin E C, Frangione B
Proc Natl Acad Sci U S A. 1971 Jan;68(1):187-91. doi: 10.1073/pnas.68.1.187.
A gamma1 protein, designated CRA, found in heavy chain disease contains three inter-heavy disulfide bridges instead of the two normally found in gamma1 immunoglobulin heavy chains. Almost the entire Fd fragment is missing. The NH(2) terminal region is heterogeneous and contains carbohydrate; after 11 residues that do not resemble any of the known heavy-chain variable-region subclasses, normal synthesis seems to be resumed at the same amino acid residue as in another heavy-chain disease protein (ZUC). This finding raises the possibility that glutamic acid at position 216 represents the beginning of the Fe region, synthesized under the direction of another gene.
在重链病中发现的一种γ1蛋白，命名为CRA，含有三个重链间二硫键，而不是γ1免疫球蛋白重链中通常存在的两个。几乎整个Fd片段缺失。NH(2)末端区域具有异质性且含有碳水化合物；在11个与任何已知重链可变区亚类都不相似的残基之后，正常合成似乎在与另一种重链病蛋白（ZUC）相同的氨基酸残基处恢复。这一发现增加了216位谷氨酸代表在另一个基因指导下合成的Fe区域起始点的可能性。
